{"id":"W4386324730","doi":"10.3390/biom13091333","title":"ABCD1 Transporter Deficiency Results in Altered Cholesterol Homeostasis","year":2023,"lang":"en","type":"article","venue":"Biomolecules","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Austrian Science Fund","keywords":"Adrenoleukodystrophy; ABCA1; Cholesterol; Endocrinology; Internal medicine; Liver X receptor; Peroxisomal disorder; Peroxisome; Lipid metabolism; Homeostasis; Chemistry; Biology; Transporter; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203923,0.0002259894,0.0001770721,0.0002396171,0.00005862102,0.00003400808,0.0002827266,0.0002170558,0.00001204063],"category_scores_gemma":[0.00006610257,0.0002159336,0.0001004742,0.0005958356,0.0001011122,0.000007577024,0.00007000034,0.0001067512,0.0001152315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002210478,"about_ca_system_score_gemma":0.00006243632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004898148,"about_ca_topic_score_gemma":0.0001036004,"domain_scores_codex":[0.9983276,0.00007479022,0.0003601496,0.0005760873,0.00018865,0.0004727512],"domain_scores_gemma":[0.9993526,0.00000952864,0.00007365824,0.0004134891,0.0000419462,0.0001088213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001797197,0.00008598925,0.003338068,0.00002044444,0.00002018761,0.00001901424,0.0001467555,0.00002365473,0.9889555,0.00001990235,0.002194572,0.004996188],"study_design_scores_gemma":[0.001450338,0.0002002991,0.0221445,0.00003000565,0.000007670162,0.0000109164,0.0001429512,0.00003184491,0.9629872,0.00002774339,0.01263976,0.0003267793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975107,0.000429175,0.0001726302,0.0005324468,0.000228192,0.0002228564,0.0001416539,0.00007882105,0.0006835156],"genre_scores_gemma":[0.9982961,0.0004177112,0.0001452096,0.0002119033,0.0001231508,0.00005070829,0.0005280315,0.00004129857,0.0001858899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02596831,"threshold_uncertainty_score":0.8805516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680053733975965,"score_gpt":0.2668436659480443,"score_spread":0.2500431286082846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}