{"id":"W4386324730","doi":"10.3390/biom13091333","title":"ABCD1 Transporter Deficiency Results in Altered Cholesterol Homeostasis","year":2023,"lang":"en","type":"article","venue":"Biomolecules","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Austrian Science Fund","keywords":"Adrenoleukodystrophy; ABCA1; Cholesterol; Endocrinology; Internal medicine; Liver X receptor; Peroxisomal disorder; Peroxisome; Lipid metabolism; Homeostasis; Chemistry; Biology; Transporter; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322974,0.0006155537,0.0004510057,0.0006067858,0.000279224,0.0004548843,0.0002167074,0.0007170181,0.004633063],"category_scores_gemma":[0.0001769363,0.0002430634,0.0004195305,0.0003861904,0.0004611105,0.0001768827,0.0003711313,0.0006731988,0.001177212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632504,"about_ca_system_score_gemma":0.0001939356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007852988,"about_ca_topic_score_gemma":0.0008422498,"domain_scores_codex":[0.999632,0.00004858166,0.00005639669,0.000114305,0.00009520813,0.00005354768],"domain_scores_gemma":[0.9997919,0.00003189741,0.00006659871,0.00002035948,0.00001711013,0.00007207537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003245436,0.00003432448,0.000990534,0.00006174484,0.00001692775,0.0009692585,0.00003081431,0.00003420841,0.9955525,0.0001219487,0.0001048845,0.001758144],"study_design_scores_gemma":[0.0001098704,0.000430309,0.03832248,0.00004113772,0.000135469,0.01155508,0.0002289966,0.0008770571,0.9375615,0.0002911091,0.01042106,0.0000260554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920294,0.002231279,0.001834867,0.0002051226,0.00008902259,0.00002868519,0.001826513,0.0002113634,0.001543616],"genre_scores_gemma":[0.9897283,0.001757699,0.001167987,0.0001191862,0.00002042663,0.000051172,0.001360029,0.0000790074,0.00571611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004633063,"threshold_uncertainty_score":0.01549917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680053733975965,"score_gpt":0.2668436659480443,"score_spread":0.2500431286082846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}