{"id":"W4386324919","doi":"10.1038/s43587-023-00471-5","title":"A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases","year":2023,"lang":"en","type":"article","venue":"Nature Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Parkinsonfonden; Hjärnfonden; Fondation Brain Canada; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Gamla Tjänarinnor; Lunds Universitet; Skånes universitetssjukhus; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Weston Brain Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Australian Government","keywords":"Medicine; Workflow; Positron emission tomography; Internal medicine; Oncology; Cognitive impairment; Disease; Nuclear medicine; Database; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002931955,0.0002188129,0.0002804919,0.0003734964,0.0001203474,0.00003630199,0.00008423558,0.0001069698,0.00001725147],"category_scores_gemma":[0.000384446,0.0001680024,0.00006552764,0.0008444285,0.00003848083,0.00006603396,0.00003084728,0.0004640543,0.00004272765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668413,"about_ca_system_score_gemma":0.0004502955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877079,"about_ca_topic_score_gemma":0.0005238373,"domain_scores_codex":[0.9983515,0.00007182045,0.000141967,0.0004068722,0.0004648927,0.0005629431],"domain_scores_gemma":[0.9981826,0.001048702,0.00004443367,0.0002709158,0.0001368558,0.0003164932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007535059,0.0007940831,0.9228394,0.0003118519,0.001672285,0.01240006,0.0003097834,0.002582442,0.0003848352,0.0001223974,0.002155893,0.04889189],"study_design_scores_gemma":[0.03246565,0.004216638,0.832843,0.00785218,0.0008420876,0.0003611254,0.001071617,0.1134357,0.004431541,0.0001127648,0.001184172,0.001183479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922655,0.0005275683,0.00007617969,0.00246886,0.00004709106,0.001632257,0.0001634902,0.0002181211,0.002600957],"genre_scores_gemma":[0.9933922,0.000001493716,0.00462892,0.001465651,0.0001204337,0.0001335632,0.0001455133,0.00005111544,0.00006114486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1108533,"threshold_uncertainty_score":0.6850941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03368522236708857,"score_gpt":0.3425112541801509,"score_spread":0.3088260318130623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}