{"id":"W4386325558","doi":"10.12688/f1000research.132952.2","title":"Identification of high-performing antibodies for Superoxide dismutase [Cu-Zn] 1 (SOD1) for use in Western blot, immunoprecipitation, and immunofluorescence","year":2023,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Genentech; Mitacs; Motor Neurone Disease Association; Government of Canada; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Bayer; ALS Society of Canada; Ontario Genomics; Genome Canada; Bristol-Myers Squibb; Pfizer; ALS Association","keywords":"Western blot; SOD1; Neurodegeneration; Antibody; Superoxide dismutase; Biology; Immunoprecipitation; Immunofluorescence; Molecular biology; Amyotrophic lateral sclerosis; Oxidative stress; Immunology; Medicine; Gene; Genetics; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002856841,0.0003582341,0.0008649417,0.0009856599,0.0001972595,0.000246027,0.0005799256,0.0004086417,0.00002116051],"category_scores_gemma":[0.00279529,0.0003266689,0.0001920778,0.0004349595,0.0005045868,0.0003803434,0.001140772,0.0008666114,0.00001869545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398675,"about_ca_system_score_gemma":0.0004702858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004940188,"about_ca_topic_score_gemma":0.0004664723,"domain_scores_codex":[0.9956217,0.000214298,0.001251055,0.0009753337,0.001083753,0.0008538749],"domain_scores_gemma":[0.9953121,0.001847709,0.0002484999,0.001037,0.001367403,0.0001872713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004683572,0.0005099604,0.2584877,0.009590708,0.0004778915,0.00002900563,0.003636247,0.0003480098,0.7098778,0.0004008975,0.001835593,0.0101226],"study_design_scores_gemma":[0.003170867,0.000544376,0.9351714,0.00218325,0.00009423218,0.000006688732,0.0004172977,0.01146886,0.0442099,0.002213606,0.0001532153,0.0003663198],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987965,0.0007547811,0.002310571,0.001736881,0.0002637014,0.005880155,0.001007649,0.00007903652,0.000002258788],"genre_scores_gemma":[0.9856828,0.003242036,0.003789743,0.00001933869,0.0001717906,0.002233217,0.001438935,0.0001540944,0.003267981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6766837,"threshold_uncertainty_score":0.9999185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09753846487308164,"score_gpt":0.3840156451767812,"score_spread":0.2864771803036995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}