{"id":"W4386326200","doi":"10.7554/elife.89331.2.sa3","title":"Author Response: PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Islamic Development Bank; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; Gene silencing; Repressor; Activator (genetics); Rap1; Antigenic variation; Cell biology; Gene; Transcription factor; Genetics; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0004307993,0.001095703,0.001044858,0.0003724697,0.0008365382,0.001795048,0.0008503619,0.002405921,0.2068309],"category_scores_gemma":[0.001384701,0.0003096714,0.0004106882,0.0003224196,0.0006504534,0.0005937724,0.001184458,0.001646383,0.065523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000915077,"about_ca_system_score_gemma":0.0006106354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000509224,"about_ca_topic_score_gemma":0.0008605283,"domain_scores_codex":[0.9992154,0.00007522932,0.00004303674,0.0003252801,0.0001602055,0.0001808807],"domain_scores_gemma":[0.9991042,0.0001755204,0.00007893138,0.00004703393,0.0002931583,0.000301083],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007202557,0.0005076546,0.003741099,0.003125088,0.0001298834,0.002414459,0.0005388691,0.002296946,0.1777443,0.004238571,0.6790344,0.1190262],"study_design_scores_gemma":[0.0006376527,0.001053702,0.01761637,0.000337486,0.0001066124,0.001827628,0.001690047,0.005302347,0.07705447,0.00328828,0.8909485,0.0001369129],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.2228792,0.04045448,0.01383265,0.1816714,0.1707848,0.001199425,0.01396498,0.007779462,0.3474335],"genre_scores_gemma":[0.2413408,0.009447804,0.002569013,0.02257557,0.01243157,0.0004369428,0.006652104,0.0008285876,0.7037175],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.9995692,"threshold_uncertainty_score":0.6919181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07456160353256129,"score_gpt":0.3889211462771313,"score_spread":0.31435954274457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}