{"id":"W4386327116","doi":"10.3389/fonc.2023.1220459","title":"MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Unicancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Osteosarcoma; Cancer research; Apoptosis; microRNA; Cell culture; Cytotoxic T cell; Downregulation and upregulation; Biology; Chondrosarcoma; Suppressor; Medicine; Internal medicine; Pathology; Cancer; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002260579,0.0003974419,0.0003379938,0.0003974249,0.0003026103,0.0003940443,0.000127954,0.0001967514,0.001103068],"category_scores_gemma":[0.0001595526,0.0002002216,0.0002787976,0.0003570394,0.0001963919,0.000158232,0.0002178699,0.0003957091,0.0005337567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421622,"about_ca_system_score_gemma":0.0003612849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000976255,"about_ca_topic_score_gemma":0.001284179,"domain_scores_codex":[0.9996977,0.0000409626,0.00003083033,0.00005381773,0.0001344824,0.00004230326],"domain_scores_gemma":[0.9999267,0.00001526272,0.00001851296,0.000009058925,0.00001626387,0.00001433062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009947892,0.00002356969,0.0002224535,0.0000525875,0.000006066246,0.00004635779,0.00003071775,0.00006888029,0.9968436,0.00008413161,0.00007059893,0.002451611],"study_design_scores_gemma":[0.00001797049,0.0002505059,0.002799238,0.000004843681,0.00002031641,0.0002163276,0.00003092953,0.0007006148,0.9904287,0.00004802402,0.005478109,0.000004567234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814183,0.005774648,0.006382621,0.0002047614,0.00006646652,0.00007924742,0.0008874664,0.0004537315,0.004732723],"genre_scores_gemma":[0.9889481,0.001873793,0.004417734,0.0001097088,0.00001595296,0.00006173264,0.001427967,0.00003788558,0.003107201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103068,"threshold_uncertainty_score":0.003690124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006632936227425126,"score_gpt":0.2687077731740194,"score_spread":0.2620748369465943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}