{"id":"W4386331901","doi":"10.20944/preprints202308.1964.v1","title":"DG9, a Versatile Cell-Penetrating Peptide to Enhance Delivery of Antisense Oligonucleotide-Based Therapeutics","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Muscular Dystrophy Canada; University of Alberta; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Oligonucleotide; Morpholino; Peptide; Cell-penetrating peptide; Cell; Chemistry; Combinatorial chemistry; Biochemistry; DNA; Gene; Zebrafish","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012548,0.0004842399,0.0002375145,0.0002685233,0.0001546862,0.0003058792,0.0002402971,0.0005085611,0.002058091],"category_scores_gemma":[0.0001212125,0.0001504199,0.0001989347,0.0002356493,0.0002503598,0.0002738843,0.0002694517,0.0006231165,0.001232329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202808,"about_ca_system_score_gemma":0.0001562989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002393774,"about_ca_topic_score_gemma":0.0002421174,"domain_scores_codex":[0.9998776,0.00001277321,0.00001049842,0.000046081,0.00003463837,0.00001839527],"domain_scores_gemma":[0.9999471,0.00001172123,0.00001518367,0.000006112083,0.000006174601,0.00001375767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002256409,0.000004471635,0.00002275744,0.0000245619,0.00000156092,0.00003754928,0.00000514363,0.00005743054,0.9981766,0.0001972834,0.00006525942,0.00138486],"study_design_scores_gemma":[0.00001275804,0.00008655559,0.0002979456,0.000004306695,0.000007132533,0.0003656561,0.00000444641,0.0004820306,0.9922343,0.0001064938,0.006394699,0.000003651498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7960154,0.01243893,0.1693249,0.0009774768,0.0005332991,0.000382808,0.003090723,0.002141969,0.01509448],"genre_scores_gemma":[0.9084834,0.005656345,0.06527567,0.0002447915,0.00008379162,0.0001231403,0.002328101,0.0002848843,0.01751972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058091,"threshold_uncertainty_score":0.006884992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08881097130215712,"score_gpt":0.3479224462097696,"score_spread":0.2591114749076124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}