{"id":"W4386332461","doi":"10.1038/s43018-023-00625-9","title":"Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation","year":2023,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"Agence Nationale de la Recherche","keywords":"Epigenetics; Gene silencing; Multiple myeloma; Biology; Cancer research; Allele; Enhancer; Gene; Immunotherapy; Genetics; Gene expression; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003881636,0.0001685679,0.0002717338,0.0001502705,0.0001544239,0.0003018499,0.0001976946,0.0003196198,0.001113798],"category_scores_gemma":[0.0003275899,0.00009726759,0.0002893316,0.0001574881,0.0002650715,0.000193345,0.0002826928,0.0006027467,0.0001705368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005014259,"about_ca_system_score_gemma":0.000176486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005584885,"about_ca_topic_score_gemma":0.001409409,"domain_scores_codex":[0.9998494,0.00002467777,0.000008757248,0.00003794312,0.00003301624,0.00004614136],"domain_scores_gemma":[0.9998897,0.00002682516,0.00002645593,0.00002422829,0.00001152636,0.00002117024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004098244,0.0006024744,0.0866623,0.0002319524,0.000219645,0.002706057,0.0003167757,0.001587152,0.7524916,0.001212175,0.00252456,0.147347],"study_design_scores_gemma":[0.002106032,0.01860663,0.3674193,0.0000758907,0.0006944196,0.02920261,0.0004101114,0.01013394,0.5369083,0.001507076,0.03286895,0.00006674854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966983,0.0006374365,0.0008153713,0.0002709112,0.0000106728,0.00002977006,0.0001129827,0.00004698582,0.00137764],"genre_scores_gemma":[0.9987269,0.000237848,0.0003970034,0.0001491123,0.00000516193,0.00001304856,0.0001554109,0.000006390324,0.000309211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113798,"threshold_uncertainty_score":0.003726065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193617940110326,"score_gpt":0.3180440978058537,"score_spread":0.2961079184047504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}