{"id":"W4386332862","doi":"10.1038/s42255-023-00873-0","title":"A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels","year":2023,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Common Fund; Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Neurological Disorders and Stroke; Oulun Yliopisto; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional; NIH Office of the Director; Intellectual and Developmental Disabilities Research Center; National Institutes of Health; Texas Children's Hospital; Instituto Politécnico Nacional; Huffington Foundation","keywords":"Neurodegeneration; Ceramide; Mitochondrion; Biology; Cell biology; Biochemistry; Metabolism; Cytoplasm; Internal medicine; Apoptosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562796,0.00143305,0.0008083893,0.001572154,0.0005082914,0.0005260336,0.0009201685,0.001362321,0.005907035],"category_scores_gemma":[0.0005683905,0.000512864,0.0007026262,0.0007628266,0.001357144,0.0005161933,0.0007573644,0.001636104,0.001054344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006566388,"about_ca_system_score_gemma":0.0004392858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001388549,"about_ca_topic_score_gemma":0.001079817,"domain_scores_codex":[0.9993722,0.0001163346,0.0001019669,0.0001364128,0.0001448405,0.0001281938],"domain_scores_gemma":[0.9989778,0.0002370472,0.0002568665,0.0001284989,0.00004968281,0.0003501115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164161,0.0001396695,0.00035465,0.00003622404,0.0000397347,0.0008249431,0.00002515571,0.0001009326,0.9958524,0.0002918671,0.0001311264,0.001039201],"study_design_scores_gemma":[0.000181064,0.0004663258,0.003672206,0.00001080131,0.00006465758,0.002808269,0.00006380935,0.0008777775,0.9902849,0.0002473181,0.001302123,0.00002066035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890478,0.0009322454,0.005245574,0.0005465758,0.0002057825,0.00008458103,0.001674482,0.0004147369,0.0018482],"genre_scores_gemma":[0.9939116,0.0004371867,0.001706895,0.0001121871,0.00003032777,0.00005859097,0.0006835145,0.0001351656,0.002924577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005907035,"threshold_uncertainty_score":0.01976097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009300346374706902,"score_gpt":0.2567226829713481,"score_spread":0.2474223365966413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}