{"id":"W4386348952","doi":"10.1097/01.aoa.0000946284.09753.b4","title":"Local Anesthetic Cardiac Toxicity is Mediated by Cardiomyocyte Calcium Dynamics","year":2023,"lang":"en","type":"article","venue":"Obstetric Anesthesia Digest","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Cardiotoxicity; Medicine; Ropivacaine; Local anesthetic; Anesthesia; Anesthesiology; Anesthetic; Bupivacaine; Blockade; Calcium channel; Sodium channel; Perioperative; Pharmacology; Toxicity; Calcium; Cardiology; Internal medicine; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002902696,0.0002092682,0.0001816028,0.0002191901,0.0001753437,0.0004843511,0.0001535315,0.0002643376,0.002359703],"category_scores_gemma":[0.0002259767,0.0001245101,0.0002212898,0.00015157,0.0003420866,0.000319452,0.0002600666,0.0004954082,0.0004793925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434041,"about_ca_system_score_gemma":0.0002395254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004195659,"about_ca_topic_score_gemma":0.000530705,"domain_scores_codex":[0.9998456,0.00002571119,0.00002010152,0.00002969336,0.00005578027,0.0000230563],"domain_scores_gemma":[0.9998792,0.00002003769,0.00004584228,0.00001048417,0.00003279511,0.00001151032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004718039,0.0001237585,0.005867323,0.0003914064,0.00005580458,0.0008627022,0.0001204612,0.0001245455,0.9369231,0.002736602,0.002118448,0.05020408],"study_design_scores_gemma":[0.000201782,0.003339246,0.2187932,0.0002788937,0.0002670423,0.009963301,0.0005225309,0.002801052,0.7255251,0.003843886,0.03441573,0.00004822003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8791867,0.0725349,0.01408206,0.004715556,0.001113529,0.0001617136,0.0004989729,0.0002563567,0.02745015],"genre_scores_gemma":[0.9725041,0.01876215,0.003127393,0.0006739704,0.0002138987,0.00007283079,0.000145639,0.00001414948,0.004485939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359703,"threshold_uncertainty_score":0.007894039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240090416974212,"score_gpt":0.2743709607301646,"score_spread":0.2419700565604225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}