{"id":"W4386349084","doi":"10.1158/1078-0432.c.6717743.v2","title":"Data from A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma","year":2023,"lang":"en","type":"preprint","venue":"","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Olaparib; PARP inhibitor; PARP1; Cancer research; DNA damage; Biology; Vorinostat; Ex vivo; Molecular biology; Propidium iodide; Histone deacetylase; Comet assay; Poly ADP ribose polymerase; In vivo; Chemistry; Programmed cell death; Biochemistry; Histone; DNA; Apoptosis; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003139132,0.0005085466,0.0004727992,0.0002671151,0.0001784005,0.0002201915,0.0002568531,0.0003642489,0.004035248],"category_scores_gemma":[0.0001823461,0.000117209,0.0003476484,0.0003365557,0.0001736613,0.0002868426,0.0001004751,0.0007920763,0.0008775205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004008701,"about_ca_system_score_gemma":0.0003362268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571422,"about_ca_topic_score_gemma":0.001818361,"domain_scores_codex":[0.9998005,0.0000317729,0.00003358654,0.00004078597,0.00006454925,0.00002875802],"domain_scores_gemma":[0.9998473,0.00002920012,0.00003115331,0.00002988112,0.00002931429,0.00003321675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001437958,0.0004935876,0.0003860162,0.0002370949,0.00004215295,0.0001113785,0.00002479909,0.0004462051,0.9832218,0.0001883104,0.001342261,0.01206848],"study_design_scores_gemma":[0.0001914691,0.004405812,0.004672638,0.00001190119,0.0000693999,0.000499043,0.00002970404,0.0009020788,0.9808297,0.00004823989,0.008330689,0.000009191313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657707,0.007502459,0.006037096,0.0004748007,0.0001594963,0.0003294273,0.009249081,0.0003163992,0.0101606],"genre_scores_gemma":[0.9710234,0.004072741,0.003449501,0.0002595467,0.00002612193,0.0002016207,0.01149594,0.0000404265,0.009430693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004035248,"threshold_uncertainty_score":0.0134992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2052138215616376,"score_gpt":0.3757017999317585,"score_spread":0.1704879783701208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}