{"id":"W4386353197","doi":"10.1016/j.celrep.2023.113070","title":"TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Institute on Aging; University of Texas Health Science Center at San Antonio; National Cancer Institute; National Institutes of Health; Queen's University; VHL Alliance; Neuroendocrine Tumor Research Foundation; Canadian Institutes of Health Research; University of Texas System; Cancer Research Society; U.S. Department of Veterans Affairs","keywords":"Ubiquitin ligase; Ubiquitin; Cell biology; Biology; Mutant; Transmembrane protein; Mutation; Cancer research; Receptor tyrosine kinase; HEK 293 cells; Neural crest; Signal transduction; Receptor; Gene; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003882584,0.0000829733,0.0001276589,0.00009010609,0.0001477546,0.00002714339,0.00001276777,0.00004001395,0.00006094826],"category_scores_gemma":[0.0002244029,0.00007422634,0.00001886357,0.0001611984,0.00002627106,0.00008081295,0.00002591892,0.00006092787,0.00001881788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003945574,"about_ca_system_score_gemma":0.00009752974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006181217,"about_ca_topic_score_gemma":0.000001534766,"domain_scores_codex":[0.9990485,0.00001978355,0.0003095794,0.0002213106,0.0002667408,0.0001341192],"domain_scores_gemma":[0.9994461,0.00003209703,0.0001419757,0.0001111261,0.0001625079,0.0001062127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004071551,0.0001953735,0.0403402,0.0003746783,0.00003742094,0.002486836,0.002213408,0.000007380881,0.8531338,0.00008916896,0.06924717,0.03183388],"study_design_scores_gemma":[0.0004899495,0.0000967228,0.1709257,0.0002243945,0.00005480883,0.001871005,0.000262184,0.001664947,0.6996565,0.0002165535,0.1243259,0.000211367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949814,0.0002056531,0.0001338939,0.0008529431,0.00006270433,0.0002449376,8.550706e-7,0.0001402083,0.003377382],"genre_scores_gemma":[0.9921457,0.00002400159,0.0006898676,0.0001700092,0.00003786744,0.00001676362,0.0004499273,0.00001577131,0.00645012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1534773,"threshold_uncertainty_score":0.3026862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412115406358769,"score_gpt":0.2476841191115789,"score_spread":0.2335629650479912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}