{"id":"W4386353197","doi":"10.1016/j.celrep.2023.113070","title":"TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Institute on Aging; University of Texas Health Science Center at San Antonio; National Cancer Institute; National Institutes of Health; Queen's University; VHL Alliance; Neuroendocrine Tumor Research Foundation; Canadian Institutes of Health Research; University of Texas System; Cancer Research Society; U.S. Department of Veterans Affairs","keywords":"Ubiquitin ligase; Ubiquitin; Cell biology; Biology; Mutant; Transmembrane protein; Mutation; Cancer research; Receptor tyrosine kinase; HEK 293 cells; Neural crest; Signal transduction; Receptor; Gene; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106514,0.0001827396,0.000178622,0.00016693,0.00009442713,0.0001936349,0.0001466446,0.0001567972,0.0008853581],"category_scores_gemma":[0.0001176912,0.00007123903,0.0001206188,0.00007870283,0.000189689,0.0001156453,0.0001145645,0.0003568662,0.0001560758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479764,"about_ca_system_score_gemma":0.0001593328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002385988,"about_ca_topic_score_gemma":0.0005553103,"domain_scores_codex":[0.9999235,0.00001646124,0.000007650532,0.000009350753,0.00002003764,0.00002310043],"domain_scores_gemma":[0.9999113,0.00001618696,0.00002520088,0.000009651179,0.000006699051,0.00003098328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003410422,0.00005188925,0.0002819396,0.00002168513,0.000005620224,0.00009141758,0.00001024683,0.00008415673,0.9967923,0.000111115,0.00006286545,0.002145747],"study_design_scores_gemma":[0.00003473326,0.0005863468,0.002442031,0.000002282907,0.000008648142,0.0003145149,0.00001705289,0.0005538491,0.9945826,0.0000292482,0.001426425,0.000002169701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978827,0.0006384733,0.0005837811,0.00005219749,0.00001502737,0.000007405056,0.00007856214,0.00005501835,0.0006869111],"genre_scores_gemma":[0.9980508,0.0002954417,0.0004993919,0.00001782251,0.000006230669,0.000006275994,0.0001374211,0.00001006884,0.0009767227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008853581,"threshold_uncertainty_score":0.002961874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412115406358769,"score_gpt":0.2476841191115789,"score_spread":0.2335629650479912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}