{"id":"W4386356854","doi":"10.1038/s41467-023-41103-1","title":"Nacα protects the larval fat body from cell death by maintaining cellular proteostasis in Drosophila","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN Center for Biosystems Dynamics Research; Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Otsuka Pharmaceutical; RIKEN; Takeda Science Foundation","keywords":"Proteostasis; Drosophila (subgenus); Larva; Drosophila melanogaster; Cell biology; Programmed cell death; Biology; Cell; Apoptosis; Genetics; Ecology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007538434,0.0002394846,0.0002622649,0.0001874219,0.0007743879,0.0000462961,0.00203524,0.0007722767,0.0001133269],"category_scores_gemma":[0.0002816137,0.0001928441,0.0001031316,0.0007274795,0.0002075343,0.00009564002,0.0008718089,0.002665824,0.001175116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001093614,"about_ca_system_score_gemma":0.0001008401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003211339,"about_ca_topic_score_gemma":0.0001929961,"domain_scores_codex":[0.9973442,0.001415949,0.0003484713,0.0003260041,0.00007956701,0.0004858195],"domain_scores_gemma":[0.996749,0.0007380915,0.0001521418,0.002257227,0.0000811167,0.00002243445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006425459,0.0001279256,0.0003006406,0.000004901536,0.00006107477,0.000007024911,0.0009133687,0.00000408548,0.9850699,0.005895205,0.007206846,0.0003448164],"study_design_scores_gemma":[0.001203156,0.00008697477,0.001668405,0.0000688146,0.00004162591,0.000008780577,0.00115756,0.0004044449,0.886266,0.003806307,0.1049535,0.000334486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493126,0.02851825,0.0001576989,0.01522055,0.000681777,0.002931385,0.0004357205,0.0005421516,0.002199845],"genre_scores_gemma":[0.9950672,0.0004613079,0.0005398309,0.0005459379,0.00001949059,0.0005777645,0.001481161,0.00004523229,0.00126202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09880388,"threshold_uncertainty_score":0.999635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790089083128386,"score_gpt":0.2612889049867138,"score_spread":0.24338801415543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}