{"id":"W4386365884","doi":"10.1016/j.jbc.2023.105202","title":"Pathogenic CANVAS-causing but not nonpathogenic RFC1 DNA/RNA repeat motifs form quadruplex or triplex structures","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Amirkabir University of Technology; Fox Family Foundation","keywords":"Biology; Structural motif; Genetics; RNA; DNA; Direct repeat; Gene; G-quadruplex; Genome; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007991612,0.0003915805,0.0001631156,0.0002002298,0.000175639,0.0001702432,0.0001807956,0.0004124319,0.001085513],"category_scores_gemma":[0.0002270689,0.0001136578,0.0001728436,0.0001059223,0.00024396,0.0001513389,0.0001660636,0.0002518105,0.0004271018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516894,"about_ca_system_score_gemma":0.000123849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003710356,"about_ca_topic_score_gemma":0.0005146813,"domain_scores_codex":[0.999835,0.00002376977,0.00001251996,0.00005547719,0.00004434244,0.00002883899],"domain_scores_gemma":[0.9998304,0.00002904725,0.0000556398,0.00002295162,0.00002222583,0.00003971948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002818682,0.000009882952,0.000549598,0.00002565429,0.000005822962,0.0001694795,0.00001309827,0.00003386421,0.9982449,0.00007393449,0.00002408655,0.000821492],"study_design_scores_gemma":[0.00001041785,0.0002858425,0.009812268,0.000009007106,0.00002488481,0.003660888,0.00005843592,0.0006438044,0.9829727,0.0002383029,0.002270758,0.00001264986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99431,0.0008129038,0.002691225,0.00006133598,0.0000183035,0.00001975279,0.0001728693,0.0001186725,0.001795069],"genre_scores_gemma":[0.9971258,0.0001924442,0.001547218,0.0000349359,0.000006012249,0.00001045371,0.0002704171,0.00001487271,0.0007977948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085513,"threshold_uncertainty_score":0.003631413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03144335080618708,"score_gpt":0.2712362431145436,"score_spread":0.2397928923083565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}