{"id":"W4386376328","doi":"10.1101/2023.08.31.555658","title":"Fibronectin: a natural barrier against prion infection","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Scrapie; Fibronectin; Extracellular matrix; Biology; C2C12; Extracellular; In vitro; Gene isoform; Myogenesis; Infectivity; Cell culture; Cell biology; Retrovirus; Phenotype; Virology; Myocyte; Prion protein; Virus; Genetics; Gene; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515753,0.0003206395,0.0001656242,0.0001680384,0.000165931,0.0003833715,0.0002401038,0.00027364,0.001102819],"category_scores_gemma":[0.000156742,0.0000855184,0.0001063455,0.0000817192,0.0001782929,0.0001290467,0.0001936372,0.0002633121,0.0002779228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306184,"about_ca_system_score_gemma":0.0001676574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175698,"about_ca_topic_score_gemma":0.001443765,"domain_scores_codex":[0.9998291,0.00004662037,0.00001306449,0.0000296752,0.0000459466,0.00003563851],"domain_scores_gemma":[0.9998165,0.00005095392,0.00003194922,0.00001753049,0.0000420638,0.00004105097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002452382,0.000004774842,0.0001314233,0.00003116877,0.00000281601,0.00003853045,0.000004782803,0.00001636202,0.9989991,0.00004346078,0.00003634748,0.000666752],"study_design_scores_gemma":[0.00001894659,0.0004569845,0.02108925,0.00006907275,0.00003612865,0.001140972,0.00008255786,0.00177801,0.9610944,0.0002289644,0.01398963,0.00001503059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761437,0.008623474,0.006818325,0.0003189238,0.00007830731,0.0000610271,0.0006088482,0.0001472745,0.007200109],"genre_scores_gemma":[0.9897401,0.001079198,0.00494008,0.0001259727,0.00003650925,0.00002858013,0.0004276955,0.00001906263,0.003602861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175698,"threshold_uncertainty_score":0.003689229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111920259638192,"score_gpt":0.2308554453343716,"score_spread":0.2196634193705524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}