{"id":"W4386377401","doi":"10.20944/preprints202308.2001.v2","title":"Cancer Metabolism as a Therapeutic Target and Review of Interventions","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Horizon 2020 Framework Programme; European Commission","keywords":"Warburg effect; Cancer; Anaerobic glycolysis; Cancer cell; Psychological intervention; Glycolysis; Anaerobic exercise; Reprogramming; Cell metabolism; Cancer treatment; Medicine; Cancer research; Metabolism; Bioinformatics; Biology; Cell; Internal medicine; Physiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006524391,0.0003263533,0.0006688507,0.0000912613,0.00004954484,0.000009881391,0.0004541542,0.0003033232,0.0005395055],"category_scores_gemma":[0.000242398,0.0003226689,0.0005751769,0.0001157434,0.0001423275,0.000004083317,0.001687748,0.0003703902,0.00006747564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001922936,"about_ca_system_score_gemma":0.000312498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005202379,"about_ca_topic_score_gemma":0.00007653336,"domain_scores_codex":[0.9978871,0.0001672238,0.0006063841,0.0008477621,0.0002183963,0.0002731147],"domain_scores_gemma":[0.9982089,0.0000144228,0.0004178256,0.001082412,0.0001551205,0.000121298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000396291,0.0008290652,0.06954101,0.07327447,0.006835499,0.000008607354,0.001013226,0.0002682283,0.8030533,0.00250403,0.01307353,0.02920272],"study_design_scores_gemma":[0.0006334224,0.00003554067,0.110347,0.00818208,0.0009646564,0.00001321001,0.00004626664,0.00000754022,0.1309275,0.002492259,0.7456847,0.0006657884],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2961065,0.6953378,0.0002164646,0.00131937,0.003858993,0.00121033,0.0003468482,0.0000628466,0.001540902],"genre_scores_gemma":[0.324361,0.6667372,0.0001776189,0.0008690882,0.001184389,0.000690255,0.0002663228,0.00008181288,0.005632322],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7326112,"threshold_uncertainty_score":0.9999225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.12397029339527,"score_gpt":0.3992924334415116,"score_spread":0.2753221400462415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}