{"id":"W4386380249","doi":"10.3390/pharmaceutics15092265","title":"Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"British Columbia Institute of Technology; University of British Columbia","funders":"University of British Columbia","keywords":"Buccal administration; Bioavailability; Pharmacology; Drug delivery; Mucoadhesion; Saliva; Insulin; Glucagon-like peptide-1; Drug; Peptide; Chemistry; Medicine; Diabetes mellitus; Drug carrier; Type 2 diabetes; Biochemistry; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833004,0.0004839099,0.0004181006,0.0003054663,0.0002262182,0.0006774534,0.0007915655,0.001224429,0.001382668],"category_scores_gemma":[0.00021473,0.0003461018,0.0004988995,0.0001600524,0.0002569226,0.0008059109,0.0003418699,0.0009459795,0.001097672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128947,"about_ca_system_score_gemma":0.0003392366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003791085,"about_ca_topic_score_gemma":0.0004597199,"domain_scores_codex":[0.9998023,0.00001985171,0.00001552487,0.00004592013,0.00009877178,0.00001770771],"domain_scores_gemma":[0.9999335,0.0000102556,0.00002576236,0.000004749551,0.00001545218,0.00001022529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001019698,0.0001563817,0.00006389295,0.0007883909,0.00002264825,0.0002294921,0.00005492516,0.0002089062,0.9420263,0.001870349,0.0009431521,0.05353349],"study_design_scores_gemma":[0.0003019029,0.003994412,0.002423547,0.0001571151,0.0002165589,0.002519174,0.00006987283,0.01113983,0.85714,0.0003685931,0.1215314,0.0001375665],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4738755,0.07684294,0.4059579,0.004183243,0.002759375,0.003661595,0.0009707671,0.003506939,0.02824171],"genre_scores_gemma":[0.5936311,0.02775883,0.3515801,0.00149208,0.0003912957,0.001716005,0.0004897891,0.0001506433,0.02279009],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001382668,"threshold_uncertainty_score":0.004625499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09706364958064287,"score_gpt":0.4143218590821824,"score_spread":0.3172582095015395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}