{"id":"W4386380249","doi":"10.3390/pharmaceutics15092265","title":"Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"British Columbia Institute of Technology; University of British Columbia","funders":"University of British Columbia","keywords":"Buccal administration; Bioavailability; Pharmacology; Drug delivery; Mucoadhesion; Saliva; Insulin; Glucagon-like peptide-1; Drug; Peptide; Chemistry; Medicine; Diabetes mellitus; Drug carrier; Type 2 diabetes; Biochemistry; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001388079,0.000647852,0.000945392,0.0004139241,0.0006028367,0.00003657827,0.0004652748,0.0004851074,0.0001575039],"category_scores_gemma":[0.0004083925,0.0006500313,0.0003679547,0.0008228088,0.0007257441,0.0003314517,0.0002414519,0.0007926192,0.0000792766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861071,"about_ca_system_score_gemma":0.0004190935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007728551,"about_ca_topic_score_gemma":0.00001877394,"domain_scores_codex":[0.9960562,0.0005447207,0.001017704,0.0008669929,0.0003168362,0.001197534],"domain_scores_gemma":[0.993886,0.003781644,0.0005345859,0.000354984,0.0008578743,0.0005849411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01948241,0.00324889,0.01983192,0.004575562,0.007642346,0.0002393558,0.02866115,0.05019681,0.4870953,0.008592691,0.2287899,0.1416437],"study_design_scores_gemma":[0.009357127,0.0005438527,0.0002875151,0.00008833693,0.0006832014,0.00006403017,0.003638335,0.101192,0.2399112,0.00153165,0.6418405,0.0008622383],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831094,0.004526556,0.001521004,0.0008728582,0.00286458,0.002986772,0.003340338,0.0003814803,0.0003970355],"genre_scores_gemma":[0.9889928,0.00336212,0.0009096151,0.002397845,0.000586225,0.0005765352,0.0006460337,0.0001377693,0.002391079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4130507,"threshold_uncertainty_score":0.9995951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09706364958064287,"score_gpt":0.4143218590821824,"score_spread":0.3172582095015395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}