{"id":"W4386385012","doi":"10.1021/acs.estlett.3c00410","title":"Lifetime Postnatal Exposure to Perfluoroalkyl Substance Mixture and DNA Methylation at Twelve Years of Age","year":2023,"lang":"en","type":"article","venue":"Environmental Science & Technology Letters","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Environmental Health Sciences; Centers for Disease Control and Prevention","keywords":"DNA methylation; Methylation; CpG site; Differentially methylated regions; KEGG; Medicine; Physiology; Biology; Internal medicine; Gene; Bioinformatics; Genetics; Gene expression; Transcriptome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003314,0.0001706131,0.0001507592,0.0002802425,0.0001989119,0.0002238968,0.0001755541,0.0003120239,0.002088898],"category_scores_gemma":[0.0008644674,0.000155949,0.0001893598,0.0002651259,0.00009511776,0.0001685225,0.0001850819,0.0002436195,0.0002038347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001804031,"about_ca_system_score_gemma":0.000158271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008245974,"about_ca_topic_score_gemma":0.007577708,"domain_scores_codex":[0.9998661,0.00002084914,0.000009380647,0.00005279854,0.00002294228,0.00002793446],"domain_scores_gemma":[0.9996343,0.00005387461,0.0001576813,0.00002914035,0.00006065423,0.00006443016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002483748,0.00002650486,0.9929968,0.000009293455,0.00002949359,0.00007984234,0.00007926725,0.000042287,0.003326216,0.00001933582,0.00008102901,0.003061632],"study_design_scores_gemma":[0.000001149038,0.00006174759,0.9990533,0.000002890478,0.00001656542,0.00009870541,0.00003720788,0.0000793329,0.0005011498,0.00001039837,0.0001362983,0.000001288592],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986455,0.0002062261,0.0001353216,0.00002197464,0.000002123012,0.000002247906,0.0007652101,0.00000416664,0.000217228],"genre_scores_gemma":[0.9985821,0.0001813785,0.0001543369,0.0000114428,0.000002720857,0.000007229413,0.0004654068,0.000002681501,0.0005927585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008245974,"threshold_uncertainty_score":0.01639593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006639402862748505,"score_gpt":0.2288370814149256,"score_spread":0.2221976785521771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}