{"id":"W4386386704","doi":"10.1021/jacs.3c03058","title":"Superior Photoprotection of Cyanine Dyes with Thio-imidazole Amino Acids","year":2023,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Consejo Nacional de Ciencia y Tecnología; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; National Medical Research Council; Canada Foundation for Innovation","keywords":"Chemistry; Cyanine; Photobleaching; Photoprotection; Fluorophore; Photochemistry; Fluorescence; Quenching (fluorescence); Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332812,0.0001110975,0.0002183142,0.00001382242,0.00004749028,0.000007337064,0.0003167446,0.00006108747,0.000003563291],"category_scores_gemma":[0.00008073961,0.00006930584,0.0002551405,0.0003316125,0.0005010726,0.00000654985,0.0001323898,0.0002228663,4.866538e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002961339,"about_ca_system_score_gemma":0.00005997019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001287277,"about_ca_topic_score_gemma":5.572001e-7,"domain_scores_codex":[0.9992512,0.00002446931,0.0002308367,0.0001276307,0.0001973838,0.0001684147],"domain_scores_gemma":[0.9992026,0.00001502503,0.000410044,0.0002196507,0.0001082831,0.00004440045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001278157,0.00002917679,0.004040342,0.00001164013,0.00005646699,7.723026e-7,0.00007463312,0.00002402005,0.9936274,9.546674e-7,0.001204054,0.0008027509],"study_design_scores_gemma":[0.0001793192,0.0003243176,0.003184936,0.00004269527,0.00002217616,0.0000473732,0.0003252804,0.00002797268,0.994924,0.00002323006,0.0008119445,0.00008676427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963622,0.00005229851,0.003128945,0.0002898295,0.00003438208,0.00008680586,0.000006982278,0.0000151236,0.00002339923],"genre_scores_gemma":[0.9805052,0.0002319431,0.01886193,0.0002047794,0.0001317781,0.00000526413,0.000002587194,0.00001904456,0.00003752932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01585709,"threshold_uncertainty_score":0.282621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005841556669459083,"score_gpt":0.2584609563904622,"score_spread":0.2526193997210031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}