{"id":"W4386386704","doi":"10.1021/jacs.3c03058","title":"Superior Photoprotection of Cyanine Dyes with Thio-imidazole Amino Acids","year":2023,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Consejo Nacional de Ciencia y Tecnología; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; National Medical Research Council; Canada Foundation for Innovation","keywords":"Chemistry; Cyanine; Photobleaching; Photoprotection; Fluorophore; Photochemistry; Fluorescence; Quenching (fluorescence); Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094693,0.0003533028,0.0001911699,0.00009145519,0.0001102173,0.0001580447,0.0002675938,0.0002671765,0.0006555364],"category_scores_gemma":[0.0002325934,0.00007646715,0.0001340068,0.00008521938,0.0002163569,0.0002264721,0.0001793256,0.0002413876,0.0001354267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005153,"about_ca_system_score_gemma":0.0001437059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004057136,"about_ca_topic_score_gemma":0.000518242,"domain_scores_codex":[0.9998937,0.00001931687,0.000008945647,0.00002534251,0.00002417025,0.00002850462],"domain_scores_gemma":[0.9998413,0.00003722955,0.00005979413,0.0000209722,0.00001948771,0.00002105435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003713218,0.000003403557,0.00003695106,0.00001891974,0.000001680374,0.00002065649,0.000009401081,0.00002906777,0.9993911,0.00004429372,0.000005193276,0.0004022009],"study_design_scores_gemma":[0.000001486683,0.0000358575,0.0003046951,9.604331e-7,0.000001942346,0.0000576568,0.000002959615,0.0001060397,0.9992748,0.000006649951,0.0002060908,9.644938e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994181,0.0008854929,0.00406606,0.00003352687,0.00001015405,0.00001101855,0.00005068325,0.00007295598,0.0006890812],"genre_scores_gemma":[0.9965629,0.0003465497,0.002467777,0.00002057791,0.000003997668,0.000007902251,0.00007421974,0.00001602824,0.0005000253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006555364,"threshold_uncertainty_score":0.002192974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005841556669459083,"score_gpt":0.2584609563904622,"score_spread":0.2526193997210031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}