{"id":"W4386386997","doi":"10.58445/rars.403","title":"Combination of mRNA Vaccines and Immune Checkpoint Inhibitors for Cancer Treatment","year":2023,"lang":"en","type":"preprint","venue":"","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Earl Haig Secondary School","funders":"","keywords":"Cancer; Cancer research; Immune checkpoint; Cancer vaccine; Immune system; Medicine; Messenger RNA; Virology; Immunology; Biology; Immunotherapy; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004413103,0.0003509122,0.0005475378,0.0004955017,0.0001186993,0.0006194023,0.0001738408,0.0003763154,0.004071955],"category_scores_gemma":[0.0004191264,0.0001387624,0.0003821739,0.0003690017,0.0002418929,0.0004421917,0.0002860811,0.0004031355,0.0011034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003152334,"about_ca_system_score_gemma":0.0003134452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543239,"about_ca_topic_score_gemma":0.0002193521,"domain_scores_codex":[0.9996623,0.00008105893,0.00001556983,0.00004230902,0.0001672207,0.00003156328],"domain_scores_gemma":[0.9999295,0.00002926536,0.00001391795,0.000008972669,0.000009679117,0.000008665539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001196829,0.0005498641,0.001114639,0.001179537,0.0002037167,0.0005258744,0.00007651158,0.0111438,0.6273819,0.01811619,0.00726055,0.3312506],"study_design_scores_gemma":[0.0006347153,0.003081225,0.002580742,0.0001734051,0.0003410976,0.001392968,0.00006919747,0.02801162,0.7636969,0.01499323,0.1849755,0.00004928615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4432312,0.1368888,0.2946579,0.005956531,0.00320004,0.000861003,0.001078408,0.002320589,0.1118054],"genre_scores_gemma":[0.7920977,0.03554016,0.1292472,0.001091514,0.000797618,0.0005233576,0.0007240237,0.0003071035,0.03967132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004071955,"threshold_uncertainty_score":0.01362205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779202183494436,"score_gpt":0.2987742404218534,"score_spread":0.270982218586909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}