{"id":"W4386396039","doi":"10.26434/chemrxiv-2023-09l28","title":"A “Neat” Synthesis of Substituted 2-Hydroxy-pyrido[1,2-a]pyrimidin-4-ones","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; British Columbia Knowledge Development Fund; University of Victoria","keywords":"Diethyl malonate; Chemistry; Simple (philosophy); Organic chemistry; Condensation; Solvent; Malonate; Mathematics; Combinatorial chemistry; Catalysis; Thermodynamics; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002908172,0.0005916272,0.001014989,0.0001769936,0.0001379043,0.00006843651,0.001175134,0.0007915414,0.00134291],"category_scores_gemma":[0.0005720075,0.0006067705,0.0006145293,0.0002957678,0.0002993084,0.00005359185,0.0008372139,0.0006862812,0.0005109045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147989,"about_ca_system_score_gemma":0.0002405654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001908538,"about_ca_topic_score_gemma":0.00001740415,"domain_scores_codex":[0.9970858,0.00002428715,0.0009078499,0.001028529,0.0004452687,0.0005083376],"domain_scores_gemma":[0.9962751,0.0006163911,0.0006651769,0.002055491,0.0001985857,0.0001892188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007232521,0.0009998173,0.003633476,0.006801878,0.001157802,0.0000402705,0.0004668893,0.00112905,0.9692272,0.004942597,0.006028457,0.005500237],"study_design_scores_gemma":[0.0001596705,0.000002519235,0.001802005,0.0008693638,0.000343957,0.000005316414,0.000164139,0.0007070822,0.9893333,0.002495764,0.003476367,0.0006405017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636897,0.0004894098,0.0001314806,0.0008394515,0.0002784124,0.0002533172,0.000208787,0.0007053859,0.03340409],"genre_scores_gemma":[0.9947646,0.0005168247,0.0006555484,0.00001314506,0.0005232454,0.0008970893,0.0002024866,0.0001617582,0.002265337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03113875,"threshold_uncertainty_score":0.9996384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04421929401755766,"score_gpt":0.2726719833662978,"score_spread":0.2284526893487402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}