{"id":"W4386398862","doi":"10.1016/j.isci.2023.107813","title":"A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Human Genome Research Institute; Biomedical Advanced Research and Development Authority; Parker Institute for Cancer Immunotherapy; National Cancer Institute; Division of Undergraduate Education; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation","keywords":"Blockade; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Myeloid cells; Medicine; Pandemic; Immunology; Myeloid; Virology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005876432,0.000143862,0.0002211113,0.00008265987,0.0002544223,0.0000174124,0.0004417592,0.0001502249,0.0003761315],"category_scores_gemma":[0.0002371925,0.0001157803,0.00005378703,0.0009695953,0.0008731922,0.00007385994,0.00008297269,0.0002023398,0.0001069215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000102827,"about_ca_system_score_gemma":0.000419437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002006692,"about_ca_topic_score_gemma":0.00001963643,"domain_scores_codex":[0.9987233,0.0001527947,0.0002103105,0.0003507896,0.0001031609,0.0004596315],"domain_scores_gemma":[0.9991134,0.0003175467,0.0001682751,0.0002786939,0.00008100231,0.00004106148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000844032,0.0001764787,0.004907171,0.00002276499,0.0001027347,0.000005354104,0.00169697,0.00004215036,0.9804275,0.00002082944,0.004634044,0.007879592],"study_design_scores_gemma":[0.001669705,0.0005058247,0.006513061,0.00007392413,0.00006600224,0.00002149013,0.0006125399,0.0001811352,0.9177456,0.0002816844,0.07197405,0.0003549133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953784,0.00219518,0.0002644262,0.000757596,0.0002574191,0.0004096924,0.0001001753,0.0002940146,0.0003431267],"genre_scores_gemma":[0.9966477,0.00004734814,0.0000899947,0.0009451378,0.000005006035,0.00005754091,0.00005033518,0.00001301534,0.002143937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06734002,"threshold_uncertainty_score":0.4721383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409077796501139,"score_gpt":0.2909690264690001,"score_spread":0.2668782485039887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}