{"id":"W4386398862","doi":"10.1016/j.isci.2023.107813","title":"A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Human Genome Research Institute; Biomedical Advanced Research and Development Authority; Parker Institute for Cancer Immunotherapy; National Cancer Institute; Division of Undergraduate Education; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation","keywords":"Blockade; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Myeloid cells; Medicine; Pandemic; Immunology; Myeloid; Virology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002064766,0.0002115831,0.0003137295,0.0002045264,0.0001417845,0.0003006786,0.00008937235,0.0001384493,0.001351688],"category_scores_gemma":[0.0002187957,0.00007627306,0.0001643578,0.0001682327,0.000178246,0.0001446766,0.0002113579,0.0007196643,0.0001680559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001879994,"about_ca_system_score_gemma":0.0002045428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002404429,"about_ca_topic_score_gemma":0.000592379,"domain_scores_codex":[0.9998559,0.0000283314,0.00001401127,0.00002544736,0.00002926815,0.0000468909],"domain_scores_gemma":[0.999855,0.00001241551,0.0000539553,0.00001247827,0.00001261069,0.0000533979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006022899,0.0005778925,0.04405082,0.0001584049,0.00007154736,0.0002336015,0.00008298713,0.0003589513,0.9155963,0.0001203072,0.0005370078,0.03218925],"study_design_scores_gemma":[0.0005682616,0.01606402,0.7150069,0.0000514101,0.0001894351,0.002847724,0.00034951,0.002310603,0.2546006,0.0002598718,0.007726416,0.00002515128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970436,0.001056219,0.0004147879,0.00009581031,0.00001984097,0.00005066773,0.0003458877,0.00003119334,0.0009420764],"genre_scores_gemma":[0.9985781,0.0002957661,0.0002909337,0.00005678531,0.00001066032,0.00002973353,0.0003596809,0.000003590743,0.0003745871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351688,"threshold_uncertainty_score":0.004521847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409077796501139,"score_gpt":0.2909690264690001,"score_spread":0.2668782485039887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}