{"id":"W4386415573","doi":"10.1038/s41409-023-02092-3","title":"No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma","year":2023,"lang":"en","type":"letter","venue":"Bone Marrow Transplantation","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; SickKids Foundation; Hospital for Sick Children; BC Children's Hospital; University of Toronto","funders":"Cancer Moonshot; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Pharmacyclics; Takeda Oncology; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Legend Biotech; Sangamo Therapeutics; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Jazz Pharmaceuticals; StemCyte; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; BeiGene; HistoGenetics; Atara Biotherapeutics; National Cancer Institute; Gilead Sciences; Moonshot Research and Development Program; Sanofi; GlaxoSmithKline; Gateway for Cancer Research; CSL Behring; Bristol-Myers Squibb; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; Alexion Pharmaceuticals; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen","keywords":"Medicine; Hematopoietic cell; Haematopoiesis; Stem cell; Neuroblastoma; CD34; Hematopoietic stem cell transplantation; Oncology; Hematopoietic stem cell; Surgery; Transplantation; Internal medicine; Immunology; Cell culture; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002266784,0.0008678119,0.00133796,0.0007963928,0.0001727674,0.00005139589,0.0002567928,0.0007331078,0.00004917958],"category_scores_gemma":[0.00001562823,0.000724951,0.0009406992,0.0003398824,0.0001282551,0.0001224895,0.00001574943,0.001494406,0.0002450028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301096,"about_ca_system_score_gemma":0.0003189982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007544553,"about_ca_topic_score_gemma":0.0001137617,"domain_scores_codex":[0.9956132,0.0002945997,0.001077703,0.001013993,0.0009894804,0.001010981],"domain_scores_gemma":[0.9971362,0.00116616,0.0006285906,0.0006601305,0.0001449613,0.000263928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.06335241,0.006927305,0.2998067,0.1116557,0.008214069,0.07177377,0.005176268,0.004251079,0.07242773,0.00003860562,0.3530755,0.003300979],"study_design_scores_gemma":[0.05760031,0.03687405,0.7955268,0.005582815,0.01048869,0.002031502,0.00004245418,0.0008336029,0.08763421,0.0002548525,0.0001962025,0.002934513],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870184,0.00004645561,0.0002707405,0.00309748,0.0003751429,0.003453996,0.005063951,0.0003259585,0.0003478974],"genre_scores_gemma":[0.9854652,0.0005911672,0.0001525551,0.002984466,0.0004126592,0.0002616083,0.005840719,0.000331304,0.003960357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4957201,"threshold_uncertainty_score":0.9995202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616512539687787,"score_gpt":0.2674398911935789,"score_spread":0.251274765796701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}