{"id":"W4386415573","doi":"10.1038/s41409-023-02092-3","title":"No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma","year":2023,"lang":"en","type":"letter","venue":"Bone Marrow Transplantation","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; SickKids Foundation; Hospital for Sick Children; BC Children's Hospital; University of Toronto","funders":"Cancer Moonshot; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Pharmacyclics; Takeda Oncology; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Legend Biotech; Sangamo Therapeutics; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Jazz Pharmaceuticals; StemCyte; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; BeiGene; HistoGenetics; Atara Biotherapeutics; National Cancer Institute; Gilead Sciences; Moonshot Research and Development Program; Sanofi; GlaxoSmithKline; Gateway for Cancer Research; CSL Behring; Bristol-Myers Squibb; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; Alexion Pharmaceuticals; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen","keywords":"Medicine; Hematopoietic cell; Haematopoiesis; Stem cell; Neuroblastoma; CD34; Hematopoietic stem cell transplantation; Oncology; Hematopoietic stem cell; Surgery; Transplantation; Internal medicine; Immunology; Cell culture; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007307376,0.0001179077,0.0003854135,0.0002243428,0.0006652155,0.0004790812,0.0003394349,0.002142894,0.002094201],"category_scores_gemma":[0.006277313,0.0001105793,0.0004654371,0.000458034,0.0003784221,0.0003438411,0.0002632905,0.001907173,0.0003678355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00159818,"about_ca_system_score_gemma":0.001660414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007751016,"about_ca_topic_score_gemma":0.01768455,"domain_scores_codex":[0.9993916,0.000179499,0.00006223782,0.00006343885,0.0001461686,0.0001570652],"domain_scores_gemma":[0.9960609,0.002133644,0.00050106,0.0001162256,0.0003155702,0.0008725397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00224487,0.0003334172,0.8829877,0.00007026034,0.0001440669,0.02266183,0.0004162253,0.0007279786,0.001493158,0.001344248,0.0412984,0.04627795],"study_design_scores_gemma":[0.0003517771,0.002614956,0.9165469,0.0002432401,0.0004551739,0.03740349,0.001764802,0.001495395,0.001384152,0.003790511,0.03388111,0.00006841403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7776321,0.003423583,0.0002566194,0.19288,0.001954992,0.0000250445,0.0008436258,0.00003683313,0.02294717],"genre_scores_gemma":[0.9546189,0.001353049,0.0002539292,0.03929691,0.002127454,0.00001921674,0.0002989536,0.00001989808,0.002011615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007751016,"threshold_uncertainty_score":0.01541179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616512539687787,"score_gpt":0.2674398911935789,"score_spread":0.251274765796701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}