{"id":"W4386416002","doi":"10.3390/antiox12091715","title":"NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells","year":2023,"lang":"en","type":"article","venue":"Antioxidants","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"CD36; Internal medicine; Endocrinology; Kidney; Renal function; Type 2 diabetes; Diabetes mellitus; Chemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904449,0.0001812083,0.0002108667,0.0001556984,0.00004920969,0.00001938847,0.00009618687,0.0001324596,0.000005168742],"category_scores_gemma":[0.000128933,0.0001808577,0.0000452932,0.0002123376,0.0001297445,0.00002129657,0.0001428598,0.00007447582,0.000002869607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001204838,"about_ca_system_score_gemma":0.00004447674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004997244,"about_ca_topic_score_gemma":0.0000189193,"domain_scores_codex":[0.9987024,0.00008189076,0.0003326724,0.0004703893,0.0001322478,0.0002803962],"domain_scores_gemma":[0.9994351,0.00002425709,0.0001289653,0.0002123211,0.00007113625,0.0001281881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001120716,0.00005818114,0.1472775,0.00008234315,0.000006032095,0.000003161857,0.0001166028,0.0001532311,0.8516597,0.000003549398,0.00008045223,0.0004471822],"study_design_scores_gemma":[0.0005787866,0.00004158359,0.4003832,0.0001008196,0.00001025036,9.217426e-7,0.00002331442,0.001209255,0.597301,0.0001680002,0.00004623604,0.0001366567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987359,0.000498932,0.0001833111,0.00008956913,0.00006006264,0.0003250246,0.00007602229,0.00001047971,0.00002066454],"genre_scores_gemma":[0.9987538,0.0002875383,0.000392132,0.00004911775,0.00006594499,0.00001288535,0.0003860075,0.00001921057,0.00003329901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2543587,"threshold_uncertainty_score":0.7375163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119388967602924,"score_gpt":0.2479836903971239,"score_spread":0.2360447936368315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}