{"id":"W4386416002","doi":"10.3390/antiox12091715","title":"NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells","year":2023,"lang":"en","type":"article","venue":"Antioxidants","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"CD36; Internal medicine; Endocrinology; Kidney; Renal function; Type 2 diabetes; Diabetes mellitus; Chemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141495,0.0007491059,0.000722617,0.0007439432,0.0002767984,0.0004296954,0.0003470347,0.0005853346,0.002265304],"category_scores_gemma":[0.0001531315,0.0004085631,0.0007692548,0.0003044794,0.0004014525,0.0004754988,0.0003127506,0.00123115,0.0005305667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588155,"about_ca_system_score_gemma":0.0003803837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009222592,"about_ca_topic_score_gemma":0.001603471,"domain_scores_codex":[0.9996935,0.00004555678,0.00005984222,0.00007769286,0.00004450061,0.00007901771],"domain_scores_gemma":[0.9996808,0.00001405927,0.0001052818,0.00002515718,0.00003275281,0.0001420455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00178309,0.0003861985,0.0006674662,0.0001647449,0.00004518837,0.0001175804,0.00004187284,0.00007702865,0.9940871,0.0001575627,0.0001983064,0.002273916],"study_design_scores_gemma":[0.0004759191,0.00267553,0.01916837,0.00007468648,0.0002604836,0.0009806312,0.0002344177,0.001794338,0.9657264,0.0003180823,0.008253787,0.00003720509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871947,0.003265409,0.004751204,0.0004813194,0.0001185961,0.00005945887,0.001673084,0.0004976874,0.001958464],"genre_scores_gemma":[0.9799226,0.003382369,0.005920856,0.000452816,0.00005078101,0.0002519984,0.001944587,0.0001516732,0.007922232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002265304,"threshold_uncertainty_score":0.007578194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119388967602924,"score_gpt":0.2479836903971239,"score_spread":0.2360447936368315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}