{"id":"W4386419370","doi":"10.3389/fncel.2023.1223912","title":"Biomolecular alterations detected in multiple sclerosis skin fibroblasts using Fourier transform infrared spectroscopy","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Spectroscopy Techniques in Biomedical and Chemical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"Multiple Sclerosis Society","keywords":"Amyotrophic lateral sclerosis; Fourier transform infrared spectroscopy; Multiple sclerosis; Fibroblast; Chemistry; Medicine; Pathology; Disease; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273038,0.0002691741,0.0001960736,0.0005488626,0.0001658946,0.0002908147,0.0001469711,0.0003968363,0.0005075623],"category_scores_gemma":[0.0002917851,0.0001236476,0.0001856014,0.0004568669,0.0001974204,0.0002225402,0.0001977993,0.0003397051,0.0001740879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008563011,"about_ca_system_score_gemma":0.00008918854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003539722,"about_ca_topic_score_gemma":0.0006780535,"domain_scores_codex":[0.9998043,0.00003520994,0.00001366768,0.00005644429,0.0000707057,0.00001965634],"domain_scores_gemma":[0.9998485,0.00004302275,0.00004732823,0.00001355801,0.00003196122,0.00001565358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009218891,0.00002395045,0.002417572,0.0000371287,0.0000126288,0.0000875514,0.0000511667,0.00007822426,0.9925749,0.00004408915,0.00003370289,0.004546833],"study_design_scores_gemma":[0.0000216576,0.0004691335,0.1430396,0.00003100686,0.00008679504,0.00255014,0.0004108076,0.005414503,0.845382,0.0005191701,0.002037021,0.00003815951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814043,0.001810868,0.01501754,0.00008373158,0.00002810655,0.0000318293,0.0003998851,0.00008982385,0.00113405],"genre_scores_gemma":[0.9711679,0.002083681,0.02517106,0.0001059236,0.000017851,0.00007122202,0.0004299959,0.00001977096,0.0009326958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005488626,"threshold_uncertainty_score":0.001697958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03048430251072044,"score_gpt":0.2845165018286262,"score_spread":0.2540321993179058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}