{"id":"W4386420134","doi":"10.3390/cells12172196","title":"Lysophosphatidic Acid Signalling Regulates Human Sperm Viability via the Phosphoinositide 3-Kinase/AKT Pathway","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Lysophosphatidic acid; Protein kinase B; Viability assay; Cell biology; Phosphorylation; Signal transduction; Kinase; Biology; Sperm; Chemistry; Biochemistry; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144085,0.0001589866,0.0001568094,0.000204968,0.0001595546,0.0002945892,0.00009767684,0.0001554198,0.001887755],"category_scores_gemma":[0.00008464314,0.00008710688,0.0002051725,0.0001934349,0.0001139663,0.0001605391,0.0001353226,0.0003021836,0.0003396414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001953375,"about_ca_system_score_gemma":0.0002239013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007347696,"about_ca_topic_score_gemma":0.0007359164,"domain_scores_codex":[0.9999058,0.00001592358,0.00000878167,0.00002003236,0.00002421013,0.00002520961],"domain_scores_gemma":[0.9999717,0.000002966991,0.000008961665,0.000001591658,0.00000765266,0.000007075536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001459024,0.0001212259,0.003846603,0.0002652416,0.0000457327,0.0001875457,0.00007938936,0.0002107821,0.9795794,0.0003334642,0.0005523905,0.01331915],"study_design_scores_gemma":[0.0002159547,0.001296764,0.1107704,0.00005291158,0.0001840396,0.0007236723,0.0001862388,0.002828261,0.867058,0.0003776434,0.0162826,0.00002339984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975172,0.01822674,0.00162678,0.0003460603,0.000064888,0.00003857259,0.0009900007,0.0001159511,0.003418997],"genre_scores_gemma":[0.9909145,0.005046294,0.0008010313,0.00008914559,0.00001779094,0.00002758743,0.0006110817,0.000008448908,0.002484187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887755,"threshold_uncertainty_score":0.006315231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687878590571848,"score_gpt":0.2397446334466476,"score_spread":0.2228658475409291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}