{"id":"W4386420134","doi":"10.3390/cells12172196","title":"Lysophosphatidic Acid Signalling Regulates Human Sperm Viability via the Phosphoinositide 3-Kinase/AKT Pathway","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Lysophosphatidic acid; Protein kinase B; Viability assay; Cell biology; Phosphorylation; Signal transduction; Kinase; Biology; Sperm; Chemistry; Biochemistry; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005212977,0.0002116093,0.0002745494,0.00006920661,0.0003058513,0.00003891331,0.000135174,0.0001125233,0.0008956442],"category_scores_gemma":[0.0001048446,0.0001476262,0.0001906573,0.0005068559,0.0001499481,0.00006539031,0.00006423546,0.0002352816,0.001069254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009064955,"about_ca_system_score_gemma":0.00005875831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009901436,"about_ca_topic_score_gemma":0.000007536296,"domain_scores_codex":[0.998492,0.00006194073,0.0003111273,0.0003990207,0.0003577128,0.0003782161],"domain_scores_gemma":[0.9989014,0.0001903951,0.00008712838,0.0005690492,0.0001065084,0.0001455763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003852862,0.00009603331,0.005087783,0.00008832429,0.00004997367,0.0001357871,0.0003703043,0.00007554139,0.9883315,0.0001978222,0.002185159,0.003343271],"study_design_scores_gemma":[0.0005901537,0.0001948748,0.02971747,0.00008201216,0.0001131402,0.00002358222,0.0001573488,0.001102203,0.9636689,0.001559976,0.002617828,0.0001725262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951198,0.0006515922,0.0002988279,0.0005430661,0.0005515858,0.0005576301,0.000006530352,0.0003651384,0.001905832],"genre_scores_gemma":[0.9970298,0.00003061542,0.0001324029,0.0004341805,0.0003718942,0.00002147336,0.00009736959,0.00004138636,0.001840908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02466259,"threshold_uncertainty_score":0.9997085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687878590571848,"score_gpt":0.2397446334466476,"score_spread":0.2228658475409291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}