{"id":"W4386445267","doi":"10.1038/s41467-023-41144-6","title":"Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Office of Extramural Research, National Institutes of Health; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; National Institute on Aging; Brown University; Canada Foundation for Innovation","keywords":"Etiology; Preeclampsia; Medicine; Antibody; Trophoblast; Pathological; Biomarker; Hypoxia (environmental); Placenta; Fetus; Offspring; Dementia; Pregnancy; Internal medicine; Immunology; Biology; Disease; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719386,0.0002742914,0.0002551271,0.0003062416,0.0001629081,0.0004009051,0.0002142895,0.0003255801,0.001602296],"category_scores_gemma":[0.0005590389,0.0001388371,0.0001482614,0.00017304,0.0002296624,0.0002522339,0.0002232579,0.0006456197,0.0002325744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736966,"about_ca_system_score_gemma":0.0003056647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003746859,"about_ca_topic_score_gemma":0.0004215552,"domain_scores_codex":[0.9998605,0.00003386007,0.00001091079,0.00003411522,0.00003429375,0.00002623905],"domain_scores_gemma":[0.9998311,0.0000336655,0.00006670957,0.00001449745,0.00002657786,0.00002742548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002244973,0.0002177361,0.05438063,0.0006691756,0.0001194188,0.004200195,0.0002191448,0.0002204067,0.8524557,0.001692609,0.001569764,0.08201017],"study_design_scores_gemma":[0.0001651556,0.003292112,0.287636,0.0002696459,0.0004608927,0.02765652,0.0005033216,0.001976249,0.642418,0.003486529,0.03210115,0.00003447023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445395,0.0304336,0.00870316,0.001784539,0.0002001448,0.0001192832,0.0004895119,0.0001876507,0.01354251],"genre_scores_gemma":[0.9903646,0.005688109,0.001944071,0.0002813198,0.00008199314,0.0000293446,0.0001514625,0.00001116666,0.001447784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602296,"threshold_uncertainty_score":0.005360186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648721603704851,"score_gpt":0.3164594457546785,"score_spread":0.27997222971763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}