{"id":"W4386453049","doi":"10.1073/pnas.2301030120","title":"Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bijzonder Onderzoeksfonds UGent; Universiteit Hasselt; Fonds Wetenschappelijk Onderzoek; Fondation Charcot; York University; Interreg; Vlaamse regering; NYU Langone Medical Center","keywords":"Remyelination; Myelin; Microglia; Multiple sclerosis; Lipid metabolism; Cell biology; Inflammation; Biology; Foam cell; Schwann cell; Lesion; Biochemistry; Chemistry; In vitro; Central nervous system; Immunology; Macrophage; Endocrinology; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001990116,0.0001088242,0.0001056469,0.0001522367,0.000314157,0.00003338515,0.000391827,0.0001415127,0.000002400857],"category_scores_gemma":[0.0006727911,0.00009028582,0.00006878179,0.0006049783,0.0001744995,0.0001275984,0.0001118499,0.0001107611,0.000001776916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002791866,"about_ca_system_score_gemma":0.00002556019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001608627,"about_ca_topic_score_gemma":5.366321e-8,"domain_scores_codex":[0.9983358,0.00001834379,0.0004207419,0.0002611486,0.0007860829,0.0001778241],"domain_scores_gemma":[0.9990169,0.00002307234,0.0005883318,0.00001208716,0.0003259229,0.00003364197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001119096,0.00001636317,0.001299202,0.0001019247,0.000005461596,1.451508e-9,0.0002668301,0.0001453935,0.9962313,0.000237625,0.001186745,0.0004980267],"study_design_scores_gemma":[0.0002679676,0.00002510283,0.01139547,0.00004498265,0.000008099879,0.000001939877,0.0003107771,0.004075053,0.9825851,0.0009016707,0.0002858946,0.00009790195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998257,0.0002266545,0.00004661156,0.0006698812,0.00003133726,0.0002255268,0.00002042036,0.00002122495,0.000501323],"genre_scores_gemma":[0.9991237,0.0001364191,0.0004137862,0.00005799718,0.0001123502,0.00002088853,0.00001521957,0.000008140749,0.0001114789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0136461,"threshold_uncertainty_score":0.3681749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130459756390019,"score_gpt":0.2547561409794896,"score_spread":0.2417101653404877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}