{"id":"W4386453049","doi":"10.1073/pnas.2301030120","title":"Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bijzonder Onderzoeksfonds UGent; Universiteit Hasselt; Fonds Wetenschappelijk Onderzoek; Fondation Charcot; York University; Interreg; Vlaamse regering; NYU Langone Medical Center","keywords":"Remyelination; Myelin; Microglia; Multiple sclerosis; Lipid metabolism; Cell biology; Inflammation; Biology; Foam cell; Schwann cell; Lesion; Biochemistry; Chemistry; In vitro; Central nervous system; Immunology; Macrophage; Endocrinology; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648356,0.0003310902,0.0003568213,0.0002251691,0.0001357229,0.0003375114,0.0001821958,0.0004181664,0.0009074503],"category_scores_gemma":[0.0001397393,0.0001137092,0.0003012094,0.0001523446,0.0002171205,0.0002845654,0.0002538476,0.0005790548,0.0003995236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002283342,"about_ca_system_score_gemma":0.0001874346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005516165,"about_ca_topic_score_gemma":0.0006123363,"domain_scores_codex":[0.9997528,0.00004215461,0.00003177757,0.00004031988,0.00005561814,0.00007720142],"domain_scores_gemma":[0.9998603,0.00001947894,0.00004230292,0.00001265678,0.00002636239,0.00003889204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002888435,0.00002956513,0.0002417386,0.00007077759,0.000007542902,0.0000425483,0.00001815566,0.00007130318,0.9974676,0.00006882718,0.0000476288,0.001645593],"study_design_scores_gemma":[0.00002324691,0.0003297007,0.001578717,0.000009364553,0.00001960957,0.0001570729,0.0000277312,0.0005497063,0.9938071,0.00005082239,0.003442733,0.000003990946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916281,0.0047377,0.002141996,0.0002149053,0.0000400652,0.00001765361,0.0003606353,0.00007800616,0.0007810107],"genre_scores_gemma":[0.9922681,0.001920072,0.002109399,0.0001338361,0.00002342716,0.00003119916,0.0006556474,0.00002603911,0.002832158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009074503,"threshold_uncertainty_score":0.003035724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130459756390019,"score_gpt":0.2547561409794896,"score_spread":0.2417101653404877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}