{"id":"W4386465535","doi":"10.3390/biom13091347","title":"Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel’s Cartilage Morphology","year":2023,"lang":"en","type":"article","venue":"Biomolecules","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Zebrafish; Wnt signaling pathway; Neural crest; Biology; Morphogenesis; Phenotype; Cell biology; Locus (genetics); Mutant; Genetics; Craniofacial; Anatomy; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800599,0.0001359374,0.0001578368,0.00007394419,0.00005914514,0.000006859427,0.0001114184,0.0001924081,0.0000107966],"category_scores_gemma":[0.00002871987,0.0001265523,0.00006169712,0.0001344476,0.0003355922,0.000002736155,0.0001530513,0.00004207205,0.00002325921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007778558,"about_ca_system_score_gemma":0.00005816931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001708062,"about_ca_topic_score_gemma":0.00002190162,"domain_scores_codex":[0.999089,0.00005403938,0.0002150266,0.000325063,0.00007815754,0.0002386857],"domain_scores_gemma":[0.9996437,0.00001500231,0.00007313921,0.0001626352,0.00003847757,0.000067016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006847532,0.00001891672,0.004237816,0.00002020908,0.00003835342,0.00002140003,0.00004555357,0.00002214836,0.9936539,0.0001123577,0.0005177824,0.001243074],"study_design_scores_gemma":[0.0003690566,0.0001760898,0.01019036,0.00001264095,0.00001434969,0.00003766811,0.00007335242,0.00002390084,0.9877007,0.0001158719,0.001133115,0.0001528903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982994,0.0004327641,0.0005135682,0.0002733661,0.0001290971,0.0001139664,0.00001998646,0.00001667157,0.0002011884],"genre_scores_gemma":[0.9987512,0.000167957,0.0003908603,0.0001187252,0.00005807509,0.00001216352,0.000227945,0.0000143449,0.0002586766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005953215,"threshold_uncertainty_score":0.5160653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009254513575156017,"score_gpt":0.2522667873335372,"score_spread":0.2430122737583812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}