{"id":"W4386465547","doi":"10.3233/jhd-230588","title":"Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington’s Disease Prefrontal Cortex","year":2023,"lang":"en","type":"article","venue":"Journal of Huntington s Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Aging; Michael Smith Health Research BC; National Institute of Neurological Disorders and Stroke; BC Children's Hospital","keywords":"Prefrontal cortex; Phosphorylation; Blot; Genetically modified mouse; Immunohistochemistry; Huntington's disease; Cortex (anatomy); Transgene; Internal medicine; Serine; Biology; Neurodegeneration; Endocrinology; Chemistry; Neuroscience; Disease; Medicine; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006855718,0.0004237683,0.0005162891,0.0009027811,0.0001843734,0.0001643276,0.0006125881,0.00006452562,0.0003040559],"category_scores_gemma":[0.003861318,0.0004206069,0.0003109314,0.001127825,0.0001579611,0.0006111138,0.0004515268,0.0004383949,0.0001867153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003953896,"about_ca_system_score_gemma":0.0004654131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007790086,"about_ca_topic_score_gemma":0.0002116364,"domain_scores_codex":[0.9953883,0.0005519798,0.00126502,0.0007568034,0.00128356,0.0007543372],"domain_scores_gemma":[0.9971766,0.0003202731,0.0007802792,0.0004987039,0.0001420822,0.001082064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002672783,0.001120071,0.6710135,0.0001676156,0.0000125207,0.002093416,0.0003319207,0.008042236,0.312528,0.00006795658,0.001020108,0.0009299164],"study_design_scores_gemma":[0.002351771,0.00009654998,0.8927246,0.0001901799,0.00006924393,0.00000447263,0.0001096647,0.001056834,0.1022417,0.0004201528,0.0003561257,0.0003787116],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977136,0.0001382762,0.00000831029,0.0006201834,0.0005740522,0.0005488871,0.0001164098,0.00008352097,0.0001967529],"genre_scores_gemma":[0.9977672,0.0001905357,0.00004094027,0.0005433158,0.0002281933,0.00004271575,0.00003076038,0.00008305063,0.001073344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2217111,"threshold_uncertainty_score":0.9998246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02074595440854907,"score_gpt":0.2707878396709235,"score_spread":0.2500418852623745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}