{"id":"W4386466767","doi":"10.1242/dmm.050174","title":"IL-33 regulates Müller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy","year":2023,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; Sight Research UK; Fight for Sight UK; Department of Education, Northern Ireland","keywords":"Neurodegeneration; Diabetic retinopathy; Muller glia; Retina; Endocrinology; Microglia; Ciliary neurotrophic factor; Internal medicine; Biology; Retinal; Neurotransmitter; Gliosis; Neuroinflammation; Inflammation; Diabetes mellitus; Neuroscience; Cell biology; Medicine; Neurotrophic factors; Central nervous system; Stem cell; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312853,0.0004943148,0.0002599953,0.0002991885,0.0002106282,0.0003080845,0.0001378239,0.000325731,0.001071107],"category_scores_gemma":[0.000108232,0.0001561615,0.0003221692,0.0001876884,0.0003348227,0.0002417587,0.0002936418,0.000749988,0.0003045262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032355,"about_ca_system_score_gemma":0.0002183209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005413265,"about_ca_topic_score_gemma":0.000703004,"domain_scores_codex":[0.9998566,0.00003268464,0.00001382909,0.00001938273,0.00002989018,0.00004759204],"domain_scores_gemma":[0.9998695,0.000008954462,0.00006202429,0.000005925303,0.00001437028,0.00003922413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001068807,0.0001014891,0.001468103,0.0002215485,0.00001687729,0.0004654388,0.00007688413,0.0001677702,0.9924142,0.0002220621,0.0001871768,0.003589639],"study_design_scores_gemma":[0.000402416,0.002392041,0.1689042,0.0002391763,0.0003362429,0.002568401,0.0007812608,0.003152411,0.8055171,0.001210648,0.01442149,0.00007446852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833719,0.0127111,0.00169965,0.000288891,0.00006323172,0.00004654644,0.0003369152,0.00011481,0.001366958],"genre_scores_gemma":[0.9938267,0.003989942,0.0008404683,0.0001283453,0.00001880288,0.00004798412,0.0002093669,0.00001430935,0.0009240977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071107,"threshold_uncertainty_score":0.003583193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256849166656139,"score_gpt":0.1965423481850122,"score_spread":0.1839738565184508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}