{"id":"W4386466875","doi":"10.1093/brain/awad298","title":"MerTK is a mediator of alpha-synuclein fibril uptake by human microglia","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canada First Research Excellence Fund; National Institutes of Health; Compute Canada; Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; McGill University; Pfizer; Celgene; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Sanofi; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"MERTK; Microglia; Synucleinopathies; Dementia with Lewy bodies; Cell biology; Biology; Internalization; Alpha-synuclein; Parkinson's disease; Receptor tyrosine kinase; Immunology; Receptor; Pathology; Signal transduction; Medicine; Inflammation; Biochemistry; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002108053,0.000144603,0.0001732516,0.0001527985,0.0001544283,0.00004394358,0.0002703792,0.00005740771,0.0007406897],"category_scores_gemma":[0.0004354878,0.0001474966,0.00008721805,0.0005197593,0.00006496465,0.0001289598,0.00007888878,0.00009232714,0.0008270349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009054321,"about_ca_system_score_gemma":0.00002836191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000039487,"about_ca_topic_score_gemma":0.000003519339,"domain_scores_codex":[0.9984438,0.0001421864,0.0003654656,0.000414644,0.0003801325,0.0002537644],"domain_scores_gemma":[0.9992227,0.0001715502,0.0001436218,0.0003261489,0.00002679176,0.000109213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000458817,0.00001603711,0.000005587207,0.000009619066,0.000001274768,0.00001094164,0.0001864489,0.00000188515,0.7709581,0.004150638,0.224223,0.0004318824],"study_design_scores_gemma":[0.0003373199,0.00006463117,0.0000879492,0.000005750087,0.000003116327,0.000005764345,0.00001842877,0.0004772242,0.9047686,0.0006362973,0.09347712,0.0001177931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902115,0.000009054816,0.00004329229,0.007871488,0.0003018094,0.0002211426,0.000153773,0.0002922737,0.0008956506],"genre_scores_gemma":[0.9696271,0.0000314942,0.0001061769,0.00852017,0.0001098985,0.0000258683,0.00002731943,0.00005735242,0.02149461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1338105,"threshold_uncertainty_score":0.9999509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04080518607033636,"score_gpt":0.2895174458545908,"score_spread":0.2487122597842544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}