{"id":"W4386466875","doi":"10.1093/brain/awad298","title":"MerTK is a mediator of alpha-synuclein fibril uptake by human microglia","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canada First Research Excellence Fund; National Institutes of Health; Compute Canada; Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; McGill University; Pfizer; Celgene; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Sanofi; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"MERTK; Microglia; Synucleinopathies; Dementia with Lewy bodies; Cell biology; Biology; Internalization; Alpha-synuclein; Parkinson's disease; Receptor tyrosine kinase; Immunology; Receptor; Pathology; Signal transduction; Medicine; Inflammation; Biochemistry; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400215,0.0002555943,0.000218031,0.0001701686,0.0001889642,0.0003775874,0.00008733002,0.0002904382,0.0009956947],"category_scores_gemma":[0.0001537873,0.0001268266,0.000234746,0.000119882,0.0001172669,0.0001573453,0.0001740229,0.0002452764,0.0004954294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002853549,"about_ca_system_score_gemma":0.000139585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004739366,"about_ca_topic_score_gemma":0.0005134891,"domain_scores_codex":[0.9998553,0.00002397875,0.00001245389,0.000035978,0.00004254067,0.00002981481],"domain_scores_gemma":[0.999925,0.00001150642,0.00002110241,0.00001058985,0.0000174002,0.00001443491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002645513,0.00001340833,0.0008510608,0.00003632032,0.000007531234,0.0001440409,0.00004070123,0.00003645785,0.9972923,0.00003440021,0.00003074489,0.001248421],"study_design_scores_gemma":[0.00007022065,0.0008777335,0.08583589,0.00002852559,0.000075588,0.003023496,0.0002191939,0.002023562,0.9041836,0.0002362822,0.00341239,0.00001358987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961298,0.001961902,0.0008669125,0.0000458486,0.00001185953,0.00001634857,0.0002347172,0.00002673563,0.0007059485],"genre_scores_gemma":[0.9973077,0.0005935308,0.0007397456,0.00003002243,0.000006415829,0.00001784973,0.0003296453,0.000006919748,0.0009681767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009956947,"threshold_uncertainty_score":0.003330946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04080518607033636,"score_gpt":0.2895174458545908,"score_spread":0.2487122597842544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}