{"id":"W4386467988","doi":"10.21203/rs.3.rs-3200249/v1","title":"HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in familial and sporadic amyotrophic lateral sclerosis models","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"Istituto Italiano di Tecnologia; European Commission","keywords":"Amyotrophic lateral sclerosis; Neuromuscular junction; Biology; Gene knockdown; Neuroscience; Induced pluripotent stem cell; Phenotype; Oxidative stress; Cell biology; Apoptosis; Disease; Gene; Genetics; Medicine; Pathology; Endocrinology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003587848,0.0005605919,0.0004482575,0.000993562,0.0003360142,0.0005349253,0.000550936,0.0009938949,0.005499308],"category_scores_gemma":[0.0002591407,0.0003401708,0.0005409048,0.0004242043,0.0006276856,0.0003537911,0.0005813584,0.001374374,0.001126024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005731291,"about_ca_system_score_gemma":0.0003974902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002172666,"about_ca_topic_score_gemma":0.003181585,"domain_scores_codex":[0.9994899,0.00007992701,0.00004887438,0.0001062768,0.0001277173,0.0001473034],"domain_scores_gemma":[0.9996979,0.00005258149,0.00008335678,0.0000436152,0.000024635,0.00009796469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008026881,0.0001802096,0.0004782903,0.00006640494,0.00004611257,0.000438247,0.00004941484,0.000341333,0.9938474,0.0006459651,0.000691404,0.002412519],"study_design_scores_gemma":[0.0002606932,0.0005522275,0.006040547,0.00002791693,0.00006607436,0.001075619,0.0002012017,0.002962803,0.9813463,0.0004101821,0.007037793,0.00001872158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881483,0.001285579,0.003321074,0.0005073061,0.0001854284,0.00003220148,0.002529297,0.0003841531,0.003606645],"genre_scores_gemma":[0.9789191,0.0007761235,0.002927278,0.0001653705,0.00003066854,0.00007844994,0.001906143,0.0001865334,0.0150102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005499308,"threshold_uncertainty_score":0.01839697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1558932574999725,"score_gpt":0.3654310644256597,"score_spread":0.2095378069256872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}