{"id":"W4386469188","doi":"10.3389/fimmu.2023.1225957","title":"Complement factor D regulates collagen type I expression and fibroblast migration to enhance human tendon repair and healing outcomes","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Tendon Structure and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Reumatikerförbundet; Vetenskapsrådet; Karolinska Institutet","keywords":"Fibroblast; Wound healing; Tendon; Medicine; Achilles tendon; Dermal fibroblast; Fibrosis; Cartilage oligomeric matrix protein; Pathology; Cancer research; Immunology; Cell culture; Biology; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000349055,0.0003595465,0.0001980879,0.000467502,0.0001878798,0.0003846859,0.0001332322,0.0002333028,0.001475891],"category_scores_gemma":[0.0003683685,0.00009395236,0.0002406507,0.0003087393,0.000222333,0.0001026176,0.0002078734,0.0002184717,0.0002396928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005044835,"about_ca_system_score_gemma":0.0004102267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002484944,"about_ca_topic_score_gemma":0.002019,"domain_scores_codex":[0.9997582,0.00004714297,0.00001665777,0.00006317848,0.00006361633,0.00005112209],"domain_scores_gemma":[0.9998691,0.00002075555,0.00005013106,0.000009725963,0.00002997619,0.00002031256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001394213,0.00012202,0.01374297,0.0001997538,0.00005295215,0.0000952977,0.00006772127,0.000228878,0.9682013,0.00008725922,0.0002377156,0.0155698],"study_design_scores_gemma":[0.0001638368,0.002155863,0.2579569,0.00009476847,0.0001855855,0.0009512582,0.0002836387,0.003838445,0.728964,0.0002941627,0.005077051,0.00003451877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910625,0.004956619,0.002014417,0.0001370592,0.0000234841,0.00005343587,0.0005855653,0.00004610635,0.001120741],"genre_scores_gemma":[0.9964951,0.001099217,0.001272205,0.00005860382,0.00000669037,0.00003541421,0.0002811197,0.000004934383,0.0007468581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002484944,"threshold_uncertainty_score":0.004940927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591450840200798,"score_gpt":0.3072152845913106,"score_spread":0.2913007761893027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}