{"id":"W4386470839","doi":"10.1038/s41419-023-06116-0","title":"A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Microscale thermophoresis; Cell biology; Transcriptome; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006957007,0.0002300878,0.000255998,0.0001255555,0.0000996657,0.00003027538,0.00005352418,0.000053892,0.00005003641],"category_scores_gemma":[0.00009573076,0.0001962826,0.00009434109,0.0001509017,0.00005143722,0.00008983044,0.0001126834,0.00006718525,0.00002803678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002415504,"about_ca_system_score_gemma":0.0001610321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003072456,"about_ca_topic_score_gemma":0.000001853716,"domain_scores_codex":[0.9986542,0.00005377321,0.0002236746,0.0005144055,0.0002667687,0.0002872154],"domain_scores_gemma":[0.9978693,0.00003096929,0.0001122839,0.0003205212,0.0000419431,0.00162505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004084718,0.001471763,0.9594055,0.0008104261,0.0001210991,0.001355083,0.0001728123,0.000004775522,0.005249361,0.00009695324,0.0006946008,0.02653292],"study_design_scores_gemma":[0.005004601,0.0002884449,0.9800741,0.0006992394,0.0009559652,0.00000196449,0.00004428437,0.002822797,0.006706067,0.001998085,0.001165955,0.0002384618],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932131,0.005040951,0.00005457531,0.000139423,0.00005233398,0.0006777369,0.0005824471,0.00008611046,0.0001533798],"genre_scores_gemma":[0.9972517,0.0007830348,0.0004387936,0.0001210352,0.00005426748,0.00009693669,0.0008764965,0.00003240121,0.0003453397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02629446,"threshold_uncertainty_score":0.8004173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012944251850282,"score_gpt":0.2524386482343413,"score_spread":0.2323092057158385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}