{"id":"W4386471426","doi":"10.21203/rs.3.rs-3283181/v1","title":"DENND6A couples Arl8b to a Rab34/RILP/dynein complex regulating retrograde lysosomal trafficking and autophagy","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Royal Society; Royal Society of Canada; ALS Society of Canada; McGill University","keywords":"Cell biology; Dynein; Rab; Guanine nucleotide exchange factor; Autophagy; Lysosome; GTPase; Biology; Small GTPase; Axoplasmic transport; Endosome; Microtubule; Biochemistry; Signal transduction; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601703,0.0005286945,0.0004128369,0.0003776572,0.0004607993,0.0008397627,0.0007882981,0.0007438435,0.007644531],"category_scores_gemma":[0.0002836026,0.000399251,0.000353142,0.0002959983,0.0005061125,0.0004659927,0.0005541737,0.001168927,0.004775288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008133495,"about_ca_system_score_gemma":0.0002538718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005360778,"about_ca_topic_score_gemma":0.0009131843,"domain_scores_codex":[0.9997212,0.0000246379,0.00001808362,0.0001116892,0.00006482667,0.0000595379],"domain_scores_gemma":[0.9998709,0.00001777716,0.00002888988,0.00002750106,0.0000152895,0.00003970355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000585555,0.00004533507,0.0006890056,0.0001134592,0.00002606497,0.0003144262,0.00001849027,0.0003947718,0.9901345,0.001191449,0.001772975,0.004713946],"study_design_scores_gemma":[0.00006780461,0.00003262883,0.002727264,0.00000722696,0.00001212101,0.0005956557,0.00002554426,0.003040193,0.9790401,0.0004092006,0.01403215,0.000009982883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540488,0.003393787,0.01816965,0.001921128,0.0007818182,0.0000629053,0.006054005,0.001994736,0.01357332],"genre_scores_gemma":[0.9707533,0.0008118115,0.008754197,0.0003331337,0.00006220509,0.00004633507,0.005567757,0.000544992,0.01312622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007644531,"threshold_uncertainty_score":0.02557349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09187010185605628,"score_gpt":0.371246160032551,"score_spread":0.2793760581764947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}