{"id":"W4386472365","doi":"10.7554/elife.89176.1.sa2","title":"Reviewer #1 (Public Review): Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Ephrin; Receptor tyrosine kinase; Cell biology; Biology; Receptor Protein-Tyrosine Kinases; Ubiquitin ligase; Signal transduction; Ubiquitin; EPH receptor A2; Receptor; Tyrosine kinase; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01557859,0.001398002,0.002539044,0.003292385,0.002089379,0.006692179,0.004345331,0.01596359,0.08350787],"category_scores_gemma":[0.08604097,0.000939759,0.002285306,0.001742592,0.001470753,0.003656273,0.002845877,0.005722913,0.05534066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005438896,"about_ca_system_score_gemma":0.008915259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137013,"about_ca_topic_score_gemma":0.003280171,"domain_scores_codex":[0.9896716,0.002314697,0.001431915,0.001318742,0.004368715,0.0008943025],"domain_scores_gemma":[0.861805,0.009361237,0.006177153,0.003338893,0.1109593,0.008358429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002624129,0.000003490477,0.00004277459,0.0004165041,0.000007972859,0.00002249021,0.00000735235,0.000008711785,0.00004399205,0.00007881292,0.9947774,0.004564208],"study_design_scores_gemma":[0.0001327131,0.00005561515,0.0008959364,0.001689615,0.00005431031,0.000295554,0.00004911757,0.00007656177,0.0002259794,0.0005809185,0.9959062,0.00003725911],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"other","genre_scores_codex":[0.0002657306,0.01434813,0.0007379076,0.2684827,0.7041423,0.0005957907,0.001942397,0.0005781126,0.008906928],"genre_scores_gemma":[0.005272748,0.02171027,0.001158128,0.3177536,0.5781096,0.00195864,0.002355515,0.0007596589,0.07092183],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.08350787,"threshold_uncertainty_score":0.2793617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139042136240199,"score_gpt":0.3339576431450933,"score_spread":0.2200534295210734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}