{"id":"W4386474194","doi":"10.1126/sciadv.adh2023","title":"Loss of attachment promotes proline accumulation and excretion in cancer cells","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Medical Research Council; Francis Crick Institute; Cancer Research UK; Wellcome Trust","keywords":"Proline; Secretion; Amino acid; Extracellular; Extracellular matrix; Stromal cell; Cancer cell; Chemistry; Cell biology; Biochemistry; Biology; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002701253,0.00005645702,0.00007580582,0.00007726427,0.00004310531,0.000009390255,0.00009079264,0.00002544215,0.000003294965],"category_scores_gemma":[0.00003317969,0.00004931006,0.00001325265,0.0003828598,0.00023843,0.00002225724,0.00005456977,0.00002362146,8.943711e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009089548,"about_ca_system_score_gemma":0.0000834946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003462788,"about_ca_topic_score_gemma":0.000125267,"domain_scores_codex":[0.9993461,0.00001045071,0.0001122004,0.0002347766,0.0001413222,0.0001550877],"domain_scores_gemma":[0.999757,0.000004727782,0.00005769532,0.0001007612,0.00004812927,0.00003172391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001740605,0.00001215489,0.008831227,0.00002364978,0.000001117524,1.316468e-7,0.0001111551,0.001450629,0.9619836,0.00001783548,0.00001710224,0.02753399],"study_design_scores_gemma":[0.0002487581,0.00006571098,0.0359477,0.00002357894,0.000003057734,7.753733e-7,0.00008605468,0.0004348113,0.948308,0.0001527442,0.01465148,0.000077328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957215,0.003465472,0.00007951444,0.0001058708,0.0003993846,0.0001588637,0.000009443706,0.000006416797,0.00005359797],"genre_scores_gemma":[0.9964256,0.002997812,0.0002347041,0.00002322324,0.0001660498,0.00002757936,0.000008804274,0.00000348563,0.0001127178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02745666,"threshold_uncertainty_score":0.2010806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206312561917776,"score_gpt":0.3526815421099543,"score_spread":0.3306184164907766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}