{"id":"W4386474194","doi":"10.1126/sciadv.adh2023","title":"Loss of attachment promotes proline accumulation and excretion in cancer cells","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Medical Research Council; Francis Crick Institute; Cancer Research UK; Wellcome Trust","keywords":"Proline; Secretion; Amino acid; Extracellular; Extracellular matrix; Stromal cell; Cancer cell; Chemistry; Cell biology; Biochemistry; Biology; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000066906,0.0002133991,0.0002697187,0.0001378969,0.0001865243,0.0003194843,0.0001157686,0.0002257895,0.0007509267],"category_scores_gemma":[0.0001129774,0.0001288261,0.000201573,0.0001654627,0.0001426803,0.0001187698,0.0002604811,0.0004011325,0.000245656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151434,"about_ca_system_score_gemma":0.0001506814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001840012,"about_ca_topic_score_gemma":0.002308458,"domain_scores_codex":[0.9999034,0.0000121916,0.000008137435,0.00001709056,0.00003680807,0.00002227866],"domain_scores_gemma":[0.9998901,0.00002040883,0.00002320498,0.00001812155,0.00001880386,0.00002925017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007704335,0.00001612057,0.0006077522,0.00002623824,0.000005058062,0.0001017981,0.00003069197,0.00004656544,0.9981035,0.0000260949,0.0000413002,0.0009176921],"study_design_scores_gemma":[0.00002006969,0.0009578996,0.07926045,0.00001408832,0.00002826271,0.001056804,0.000206795,0.001982344,0.9107339,0.00009038713,0.005632887,0.00001615488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952401,0.001774211,0.001305565,0.00007823618,0.00002628824,0.00001237679,0.0001737939,0.0000234649,0.001365961],"genre_scores_gemma":[0.9955038,0.0007653382,0.000989122,0.00006169032,0.000007510991,0.000009474638,0.0003918199,0.000006940043,0.002264435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840012,"threshold_uncertainty_score":0.003658593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206312561917776,"score_gpt":0.3526815421099543,"score_spread":0.3306184164907766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}