{"id":"W4386474232","doi":"10.1126/sciadv.adi2050","title":"Establishment of paternal methylation imprint at the<i>H19/Igf2</i>imprinting control region","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe","funders":"National Institute of General Medical Sciences; Österreichischen Akademie der Wissenschaften","keywords":"CTCF; Imprinting (psychology); Genomic imprinting; Germline; Biology; Allele; DNA methylation; Genetics; Methylation; Epigenetics; Transcription factor; Enhancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007899726,0.00009041127,0.00009661025,0.00006071818,0.0002312211,0.00003359361,0.0003400766,0.00002962291,0.000006976059],"category_scores_gemma":[0.0001963717,0.00006473598,0.00005679677,0.0003740889,0.0003385088,0.00001767486,0.0002860738,0.00004284218,0.00001131109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001775673,"about_ca_system_score_gemma":0.00005747392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002675917,"about_ca_topic_score_gemma":0.00001484008,"domain_scores_codex":[0.9988375,0.00003007585,0.0002158757,0.0003287379,0.0002853896,0.0003024714],"domain_scores_gemma":[0.9993519,0.00002381806,0.0001724296,0.0002892959,0.0001131025,0.00004943142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004742526,0.000006045324,0.02636593,0.000009484682,0.000004661616,3.764712e-7,0.00005752717,0.001666015,0.9195409,0.00002487476,0.00002033835,0.05229909],"study_design_scores_gemma":[0.000258393,0.0001221444,0.09378149,0.00001613823,0.000006239817,0.00001390476,0.0002783041,0.0005865421,0.8992063,0.0002045423,0.005425841,0.0001001659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954332,0.00045771,0.002951531,0.0002338632,0.0002720392,0.0001454977,0.000002147949,0.00001310195,0.0004909069],"genre_scores_gemma":[0.9988977,0.0001631249,0.0003551018,0.00005872521,0.0000656914,0.00001398513,0.000003618146,0.000006662957,0.0004353646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06741557,"threshold_uncertainty_score":0.2639856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173279442549993,"score_gpt":0.2713533376844673,"score_spread":0.2596205432589674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}