{"id":"W4386474232","doi":"10.1126/sciadv.adi2050","title":"Establishment of paternal methylation imprint at the<i>H19/Igf2</i>imprinting control region","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe","funders":"National Institute of General Medical Sciences; Österreichischen Akademie der Wissenschaften","keywords":"CTCF; Imprinting (psychology); Genomic imprinting; Germline; Biology; Allele; DNA methylation; Genetics; Methylation; Epigenetics; Transcription factor; Enhancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039777,0.0002608526,0.0001295156,0.0001581473,0.0001193799,0.000194554,0.0002310493,0.000204777,0.001243899],"category_scores_gemma":[0.0001181272,0.0001247152,0.0001972055,0.00006398546,0.0003770178,0.0002117393,0.0002706982,0.0004911831,0.0002736489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002618306,"about_ca_system_score_gemma":0.0002478836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211258,"about_ca_topic_score_gemma":0.00198853,"domain_scores_codex":[0.9998957,0.00001132803,0.000006723972,0.00002864197,0.00003254853,0.00002510393],"domain_scores_gemma":[0.9998755,0.00001952706,0.00003674164,0.00002158752,0.00000978792,0.00003689572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003096828,0.000004051151,0.001367466,0.00000933579,0.000002752904,0.0001938544,0.00001492996,0.00004631039,0.9960581,0.0007356051,0.00001895622,0.001517723],"study_design_scores_gemma":[0.000007756348,0.00008452409,0.02190568,0.000003860894,0.000009421645,0.0006818919,0.00002825255,0.0006721461,0.9744042,0.0003135528,0.001884356,0.000004325844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766827,0.0006005584,0.01518775,0.0001398095,0.00003890929,0.00001359028,0.0002436706,0.0002983929,0.006794582],"genre_scores_gemma":[0.9958175,0.0001401383,0.002249677,0.00002884857,0.000004398392,0.000004196051,0.0001210505,0.00002113438,0.001613037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243899,"threshold_uncertainty_score":0.004161239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173279442549993,"score_gpt":0.2713533376844673,"score_spread":0.2596205432589674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}