{"id":"W4386475104","doi":"10.1038/s41467-023-41174-0","title":"Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Diphtheria, Corynebacterium, and Tetanus","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Waterloo","funders":"National Institute of Neurological Disorders and Stroke; Alliance de recherche numérique du Canada; University of Waterloo; Natural Sciences and Engineering Research Council of Canada; Okinawa Institute of Science and Technology Graduate University; National Institutes of Health; Government of Canada; Japan Society for the Promotion of Science; Government of Ontario; Novo Nordisk Fonden; Compute Canada","keywords":"Clostridium tetani; Ancient DNA; Metagenomics; Phylogenetic tree; Biology; Genome; Clade; Evolutionary biology; Genetics; Gene; Virology; Tetanus; Vaccination; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644214,0.0001887525,0.0001859741,0.001001798,0.0003571897,0.0004404326,0.0001122585,0.0002143179,0.001247288],"category_scores_gemma":[0.0006607975,0.0001446639,0.0001578481,0.001376072,0.000318434,0.00012048,0.0003338559,0.0002400475,0.0002124767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805731,"about_ca_system_score_gemma":0.000188453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004287536,"about_ca_topic_score_gemma":0.00716862,"domain_scores_codex":[0.9998403,0.00001822098,0.00001225134,0.00005832883,0.00003420236,0.00003663684],"domain_scores_gemma":[0.9997221,0.0000553135,0.0001072673,0.00003878311,0.00004148047,0.00003506798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007925488,0.00003956864,0.7825139,0.0003310876,0.0001753825,0.001014184,0.001598726,0.0003889336,0.1861495,0.0003414149,0.000393698,0.02626116],"study_design_scores_gemma":[0.000007657526,0.00006935858,0.9840551,0.00005484994,0.00007693067,0.001746335,0.0009349212,0.0003659703,0.008515129,0.0002062161,0.003958277,0.000009238096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965958,0.0009474744,0.0006053389,0.00004483115,0.000005162955,0.000005743949,0.001395223,0.00000775472,0.0003927327],"genre_scores_gemma":[0.9963213,0.0005444387,0.0009699303,0.00003829656,0.000008806396,0.000006601084,0.001784868,0.000007086294,0.0003187085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004287536,"threshold_uncertainty_score":0.008525193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171293005183295,"score_gpt":0.2836248613258001,"score_spread":0.2619119312739671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}