{"id":"W4386475323","doi":"10.1101/gad.351120.123","title":"Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases","year":2023,"lang":"en","type":"letter","venue":"Genes & Development","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Protein tyrosine phosphatase; Biology; Phosphatase; Extracellular; Phosphorylation; Intracellular; Proteolysis; Tyrosine; Cell biology; Receptor tyrosine kinase; Receptor; Immunoprecipitation; Monoclonal antibody; Cancer research; Gene; Antibody; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002105076,0.0005511974,0.0005244763,0.000349182,0.0008052706,0.001492278,0.0008249265,0.01060284,0.003524016],"category_scores_gemma":[0.004294847,0.0002484266,0.0006616132,0.0001882429,0.001817095,0.001690435,0.0007397506,0.01113159,0.003855629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001687296,"about_ca_system_score_gemma":0.000717057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004246119,"about_ca_topic_score_gemma":0.001188087,"domain_scores_codex":[0.9987419,0.0003116908,0.00009512971,0.0001448691,0.0005801411,0.0001262447],"domain_scores_gemma":[0.9979134,0.001272297,0.0001449201,0.00009916972,0.0003674727,0.0002026958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000399626,0.0002905027,0.0008485581,0.0004583824,0.00006308901,0.005075282,0.0001665276,0.0004432785,0.009641665,0.03335626,0.7995625,0.1496943],"study_design_scores_gemma":[0.000213975,0.0002138314,0.0004134526,0.0001037888,0.00002147167,0.002059354,0.00007770018,0.000685051,0.002778124,0.01142119,0.9819921,0.00001985358],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003524512,0.04343059,0.003683399,0.8692947,0.0613292,0.00009190393,0.00007849633,0.0002102519,0.01835693],"genre_scores_gemma":[0.04756775,0.04665668,0.004060009,0.7505788,0.1123645,0.0002313575,0.00008452441,0.00007172837,0.03838469],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01060284,"threshold_uncertainty_score":0.01224232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02738803103669908,"score_gpt":0.2943944946842276,"score_spread":0.2670064636475285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}