{"id":"W4386476440","doi":"10.1016/j.neuron.2023.08.001","title":"A new way to mitigate pathological Tau?","year":2023,"lang":"en","type":"letter","venue":"Neuron","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Neurosciences, Mental Health and Addiction; Fondation Brain Canada; ALS Society of Canada","keywords":"Neuroscience; Neuron; Pathological; Disease; Tau protein; Tau pathology; Neurodegeneration; Alzheimer's disease; Biology; Psychology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003721468,0.001154127,0.001697722,0.0008376676,0.003434603,0.00348052,0.001571996,0.04320757,0.006299414],"category_scores_gemma":[0.01056276,0.000540878,0.001470321,0.0004787374,0.006250271,0.005428171,0.002391898,0.03569949,0.004187768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003751466,"about_ca_system_score_gemma":0.004218253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002510546,"about_ca_topic_score_gemma":0.006682341,"domain_scores_codex":[0.9980288,0.0004370903,0.0002169113,0.0002592756,0.0007130961,0.0003447991],"domain_scores_gemma":[0.996407,0.001835529,0.0003058469,0.0002289906,0.0005449403,0.0006776722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003055757,0.0001423005,0.0003463485,0.0002105548,0.00006266584,0.002137024,0.0001065418,0.0001716806,0.001144824,0.02811601,0.918376,0.04888047],"study_design_scores_gemma":[0.0004797866,0.0001662529,0.0004313939,0.0002578032,0.00005188566,0.001243912,0.0002081198,0.000425953,0.0008403746,0.06717907,0.9286487,0.00006673532],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003981273,0.01387493,0.0004964312,0.9490619,0.03261793,0.00001676752,0.00003156567,0.00006175668,0.003440565],"genre_scores_gemma":[0.007769722,0.01268039,0.001002487,0.8824794,0.0797995,0.0001038399,0.00003480064,0.00004170819,0.01608826],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04320757,"threshold_uncertainty_score":0.02721894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434875815666812,"score_gpt":0.2816910545685303,"score_spread":0.2573422964118622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}