{"id":"W4386481647","doi":"10.1016/s0378-4274(23)00847-0","title":"P22-14: Towards developing a harmonized experimental protocol of embryonic zebrafish light/dark transition behavior test for Organisation for Economic Co-operation and Development (OECD) Developmental Neurotoxicity (DNT) In-Vitro Testing Battery","year":2023,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Science, Research, and Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada; National Research Council Canada","funders":"","keywords":"Zebrafish; Neurotoxicity; Battery (electricity); Protocol (science); In vitro; Cell biology; Neuroscience; Chemistry; Biology; Medicine; Physics; Biochemistry; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000796483,0.0002166506,0.0004250527,0.0004079475,0.0002254883,0.00002652885,0.0001054808,0.0001213136,0.00007451862],"category_scores_gemma":[0.0001152624,0.000208737,0.00004255562,0.00008094533,0.0001634941,0.0001758963,0.00004018419,0.0001458263,0.00002251826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006802314,"about_ca_system_score_gemma":0.001010294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001027635,"about_ca_topic_score_gemma":0.00001347566,"domain_scores_codex":[0.9981861,0.00005207376,0.0005725872,0.0004753934,0.000221343,0.0004924889],"domain_scores_gemma":[0.9992902,0.0003140074,0.000136868,0.00009849267,0.0000328252,0.0001276319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005696212,0.0001527768,0.00550441,0.0002273301,0.00001849693,0.00001855504,0.003161691,0.000006933067,0.9858599,0.000002083087,0.0006477753,0.003830404],"study_design_scores_gemma":[0.007386098,0.000617577,0.08019757,0.00005047156,0.00001974329,0.00007663695,0.0007336677,0.0007831359,0.909104,0.000002855411,0.0008272259,0.0002009909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515092,0.000003188924,0.001152032,0.005174355,0.0001141237,0.04192135,0.00002011786,0.00007594569,0.00002969187],"genre_scores_gemma":[0.8998691,0.000001300477,0.01972728,0.003479707,0.0001223538,0.07654689,0.0001908672,0.00004274048,0.00001970773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0767559,"threshold_uncertainty_score":0.8512049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0763248618181617,"score_gpt":0.3555195778298256,"score_spread":0.2791947160116639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}