{"id":"W4386485278","doi":"10.1038/s41586-023-06355-3","title":"A second update on mapping the human genetic architecture of COVID-19","year":2023,"lang":"en","type":"letter","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institute of Infection and Immunity; Centre Hospitalier Universitaire Sainte-Justine; Ottawa Hospital; Baycrest Hospital; Alberta Children's Hospital; Women's College Hospital; Kingston Health Sciences Centre; Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; BC Children's Hospital; St. Michael's Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Calgary; Queen's University; University of British Columbia; William Osler Health System; Toronto General Hospital; Public Health Ontario; Centre Hospitalier Universitaire de Sherbrooke; Montreal Heart Institute; Montreal Children's Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Montreal Clinical Research Institute; St. Paul's Hospital; Genome British Columbia; Hospital for Sick Children; Université de Montréal; University of Toronto; Université de Sherbrooke; Genome Canada; University of Ottawa; Jewish General Hospital; Simon Fraser University; London Health Sciences Centre; McGill University; McGill University Health Centre; University of Waterloo; McGill Genome Centre; Centre Hospitalier de l’Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Novo Nordisk Fonden; National Human Genome Research Institute; Wellcome Trust; Agence Nationale de la Recherche; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institute on Minority Health and Health Disparities; University of Pennsylvania; Barts Charity; Goddard Space Flight Center; Francis Crick Institute; National Institute of General Medical Sciences; National Institute for Health and Care Research","keywords":"Genome-wide association study; Biology; Coronavirus disease 2019 (COVID-19); Computational biology; Genetics; Genome; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Genetic architecture; 2019-20 coronavirus outbreak; Genetic association; Genotype; Gene; Virology; Medicine; Single-nucleotide polymorphism; Disease; Phenotype; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003857746,0.0004054101,0.0006163577,0.0006498981,0.0001779697,0.00004321378,0.0007570727,0.004256562,0.000210262],"category_scores_gemma":[0.0004917353,0.0002565411,0.000358486,0.0007027669,0.0002270628,0.00001223638,0.0001895617,0.02028924,0.0001888766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001925749,"about_ca_system_score_gemma":0.0006591508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004765224,"about_ca_topic_score_gemma":0.00007585125,"domain_scores_codex":[0.9969947,0.0001976957,0.0003550486,0.0006514319,0.001219386,0.0005816795],"domain_scores_gemma":[0.9979137,0.0005238589,0.0001852561,0.001188243,0.0001324002,0.00005660883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006365444,0.00002234524,0.0003147043,0.002035956,0.0002503266,0.001906591,0.0004290847,0.000001573962,0.00513472,0.00003755918,0.9888417,0.0009618278],"study_design_scores_gemma":[0.0008122601,0.0001508402,0.001062512,0.0002907328,0.000081196,0.0001161989,0.00003760495,0.000006477104,0.002142376,0.001389957,0.9936801,0.0002298042],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0507926,0.003351556,0.00003091023,0.93678,0.0006761925,0.001512978,0.0003300521,0.0002204015,0.006305246],"genre_scores_gemma":[0.005475044,0.000008873823,0.00005523811,0.9876164,0.004346721,0.00007108218,0.0001616677,0.0001227756,0.002142214],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05083632,"threshold_uncertainty_score":0.9999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04904904053991761,"score_gpt":0.356071829395793,"score_spread":0.3070227888558754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}