{"id":"W4386485278","doi":"10.1038/s41586-023-06355-3","title":"A second update on mapping the human genetic architecture of COVID-19","year":2023,"lang":"en","type":"letter","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institute of Infection and Immunity; Centre Hospitalier Universitaire Sainte-Justine; Ottawa Hospital; Baycrest Hospital; Alberta Children's Hospital; Women's College Hospital; Kingston Health Sciences Centre; Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; BC Children's Hospital; St. Michael's Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Calgary; Queen's University; University of British Columbia; William Osler Health System; Toronto General Hospital; Public Health Ontario; Centre Hospitalier Universitaire de Sherbrooke; Montreal Heart Institute; Montreal Children's Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Montreal Clinical Research Institute; St. Paul's Hospital; Genome British Columbia; Hospital for Sick Children; Université de Montréal; University of Toronto; Université de Sherbrooke; Genome Canada; University of Ottawa; Jewish General Hospital; Simon Fraser University; London Health Sciences Centre; McGill University; McGill University Health Centre; University of Waterloo; McGill Genome Centre; Centre Hospitalier de l’Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Novo Nordisk Fonden; National Human Genome Research Institute; Wellcome Trust; Agence Nationale de la Recherche; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institute on Minority Health and Health Disparities; University of Pennsylvania; Barts Charity; Goddard Space Flight Center; Francis Crick Institute; National Institute of General Medical Sciences; National Institute for Health and Care Research","keywords":"Genome-wide association study; Biology; Coronavirus disease 2019 (COVID-19); Computational biology; Genetics; Genome; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Genetic architecture; 2019-20 coronavirus outbreak; Genetic association; Genotype; Gene; Virology; Medicine; Single-nucleotide polymorphism; Disease; Phenotype; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003204968,0.0005567993,0.0008718556,0.001428168,0.0007076046,0.001541428,0.001010475,0.005029283,0.006039476],"category_scores_gemma":[0.01447271,0.0004415268,0.0005787693,0.00103638,0.0008751379,0.001376901,0.0009632091,0.006160972,0.0040088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001029287,"about_ca_system_score_gemma":0.001134535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002509701,"about_ca_topic_score_gemma":0.005572852,"domain_scores_codex":[0.9982876,0.000446775,0.0002594628,0.000294305,0.0005816763,0.0001301445],"domain_scores_gemma":[0.983983,0.009460074,0.0006405165,0.001178981,0.00395501,0.0007823176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002975464,0.0000443133,0.007478983,0.0005779053,0.000166605,0.002921114,0.000175711,0.00009331266,0.003836932,0.002146468,0.825918,0.156343],"study_design_scores_gemma":[0.0001155035,0.000117558,0.0131763,0.0007698797,0.0002460727,0.006017149,0.0001334502,0.0002412037,0.000924973,0.003971504,0.9742361,0.00005027694],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.009998324,0.08337489,0.009862601,0.7844648,0.0873693,0.0001164369,0.004825131,0.0007822824,0.01920635],"genre_scores_gemma":[0.05118228,0.07954112,0.01282035,0.5451471,0.2784627,0.0002736982,0.004732222,0.000312069,0.02752846],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006039476,"threshold_uncertainty_score":0.02020407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04904904053991761,"score_gpt":0.356071829395793,"score_spread":0.3070227888558754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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