{"id":"W4386492442","doi":"10.1038/s41586-023-06604-5","title":"Complete human day 14 post-implantation embryo models from naive ES cells","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Epiblast; Embryonic stem cell; Cell biology; Biology; Yolk sac; Trophoblast; Endoderm; Embryogenesis; Mesoderm; Embryo; Stem cell; Gastrulation; Germ layer; Anatomy; Genetics; Induced pluripotent stem cell; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500878,0.000144767,0.0001276756,0.00007780561,0.0001345436,0.00003992889,0.0003078945,0.0008620135,0.0000463567],"category_scores_gemma":[0.00002986061,0.0001362602,0.00007972987,0.0001468336,0.00004196018,0.000006687529,0.0001828974,0.000683015,0.0002040119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001510187,"about_ca_system_score_gemma":0.00003811536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006268669,"about_ca_topic_score_gemma":0.00007289073,"domain_scores_codex":[0.9987686,0.00009034545,0.0001371129,0.0004019336,0.0003000755,0.000301881],"domain_scores_gemma":[0.9993491,0.00003279124,0.00004998115,0.0003313383,0.0001538681,0.00008297712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003431657,0.0000162725,0.00005895569,0.000015426,0.00004496798,0.0000226794,0.00008515988,0.0003534926,0.9727486,0.0001175707,0.02622203,0.0002805229],"study_design_scores_gemma":[0.0009657494,0.0002044301,0.007447042,0.00003306045,0.00002574879,0.000007821058,0.0001753156,0.002367666,0.9446583,0.001461098,0.04223954,0.0004142453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950674,0.0005629937,0.000177179,0.0004221853,0.0002990112,0.000226371,0.001222166,0.00005045095,0.001972207],"genre_scores_gemma":[0.9885293,0.0001529353,0.00015783,0.0005305349,0.0002740557,0.00001316954,0.00713823,0.00002934843,0.003174605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02809032,"threshold_uncertainty_score":0.6648638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760641735414973,"score_gpt":0.2879621458938275,"score_spread":0.2703557285396777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}