{"id":"W4386492442","doi":"10.1038/s41586-023-06604-5","title":"Complete human day 14 post-implantation embryo models from naive ES cells","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Epiblast; Embryonic stem cell; Cell biology; Biology; Yolk sac; Trophoblast; Endoderm; Embryogenesis; Mesoderm; Embryo; Stem cell; Gastrulation; Germ layer; Anatomy; Genetics; Induced pluripotent stem cell; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003850686,0.0003814048,0.0003220439,0.0002818459,0.0001434382,0.000333376,0.0003652131,0.0004762359,0.003941212],"category_scores_gemma":[0.0001351253,0.0001533666,0.000296815,0.0001479112,0.0002634781,0.0002134609,0.0003363409,0.0006777007,0.001177773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001998209,"about_ca_system_score_gemma":0.0002346883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006086119,"about_ca_topic_score_gemma":0.0007737586,"domain_scores_codex":[0.9997732,0.00002983557,0.00003932395,0.00004769893,0.00009334991,0.00001659324],"domain_scores_gemma":[0.9998879,0.00002252241,0.00002069291,0.00003311505,0.00001851103,0.00001721965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003179907,0.00008653537,0.0004747671,0.000134976,0.00001778416,0.000281647,0.00007393099,0.000453499,0.9926631,0.000665332,0.0003850716,0.004445439],"study_design_scores_gemma":[0.00006311074,0.001965208,0.005266589,0.00003342038,0.0000892732,0.001541251,0.00006569191,0.002037502,0.9536249,0.0003190217,0.03497652,0.00001760121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.929247,0.004667216,0.03887748,0.0002002422,0.0003316015,0.0007979168,0.008688735,0.0005547722,0.01663518],"genre_scores_gemma":[0.9372098,0.003355702,0.02694449,0.0001942768,0.00002898415,0.0005516848,0.01175904,0.0001039405,0.01985205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003941212,"threshold_uncertainty_score":0.01318467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01760641735414973,"score_gpt":0.2879621458938275,"score_spread":0.2703557285396777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}