{"id":"W4386496099","doi":"10.1136/jitc-2023-007277","title":"Targeting T-cell malignancies using allogeneic double-negative CD4-CAR-T cells","year":2023,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Medicine; T cell; Cancer research; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00107001,0.0002579722,0.0006006729,0.0004040757,0.0002957696,0.00006322653,0.0002629437,0.0001416462,0.002631973],"category_scores_gemma":[0.00002662342,0.0002145624,0.0004899031,0.0006071365,0.000153764,0.0001506203,0.00003848484,0.000416737,0.00001344696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003880445,"about_ca_system_score_gemma":0.0006116625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304791,"about_ca_topic_score_gemma":0.000009222812,"domain_scores_codex":[0.9976246,0.00006846612,0.0006756472,0.0002602258,0.0007016949,0.0006693241],"domain_scores_gemma":[0.9982863,0.0002171009,0.0004325437,0.0002705022,0.0006491676,0.0001443683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004074447,0.00008215935,0.001370564,0.0002084487,0.0005114311,0.00002178415,0.001301376,0.001925561,0.9794849,0.000007335046,0.002991818,0.008020217],"study_design_scores_gemma":[0.008902804,0.0005673803,0.0004207434,0.0002905279,0.00008681051,0.00004234482,0.0007532124,0.001059608,0.9183555,0.0002238112,0.0690609,0.000236416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866644,0.009342513,0.0005659674,0.0005960634,0.001310022,0.00099722,0.00004454395,0.00005339109,0.0004258777],"genre_scores_gemma":[0.830801,0.07260696,0.009760436,0.001274117,0.003546351,0.0002934118,0.00003488021,0.0005523096,0.0811305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1558634,"threshold_uncertainty_score":0.9982798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06099437135282873,"score_gpt":0.3805189673241266,"score_spread":0.3195245959712979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}