{"id":"W4386515506","doi":"10.1101/2023.09.06.556580","title":"Activin A targets extrasynaptic NMDA receptors to improve neuronal and behavioral deficits in a mouse model of Huntington disease","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Neuroscience; Neurodegeneration; Excitatory postsynaptic potential; Huntington's disease; Receptor; Biology; NMDA receptor; Striatum; Medium spiny neuron; Internal medicine; Medicine; Disease; Inhibitory postsynaptic potential; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002515667,0.0009704183,0.0005685618,0.001045539,0.0002877448,0.0003990949,0.0003984867,0.0008180572,0.002059443],"category_scores_gemma":[0.0001001857,0.0002522266,0.0004095348,0.000322466,0.0004932304,0.0002867745,0.0003301275,0.001459582,0.0006351101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003986675,"about_ca_system_score_gemma":0.0003146668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009859331,"about_ca_topic_score_gemma":0.001792444,"domain_scores_codex":[0.9997962,0.00002102593,0.00002789933,0.00004551135,0.00006699483,0.00004243548],"domain_scores_gemma":[0.9998388,0.00001371114,0.00005066824,0.00001762622,0.00001691783,0.00006216926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003762188,0.0001545598,0.00009491055,0.0000361446,0.00001424557,0.00007420712,0.00001500189,0.0001146538,0.9975649,0.0001526802,0.0001536926,0.001248721],"study_design_scores_gemma":[0.0001368721,0.0009131568,0.001910878,0.00001827232,0.00003752076,0.0002060425,0.00003531458,0.001149248,0.9923642,0.000118228,0.003102087,0.000008183912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986072,0.001924518,0.005380225,0.0005857068,0.000179555,0.0001151999,0.002486365,0.0005491397,0.002707337],"genre_scores_gemma":[0.9559186,0.00231553,0.01158439,0.0002557175,0.00005963364,0.0003579989,0.002647191,0.000254593,0.02660645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059443,"threshold_uncertainty_score":0.006889462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03636417947161127,"score_gpt":0.2589414851740232,"score_spread":0.2225773057024119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}