{"id":"W4386516282","doi":"10.1038/s41588-023-01462-3","title":"GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification","year":2023,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Diabetes Management and Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Helmholtz Zentrum München; Lee Kong Chian School of Medicine, Nanyang Technological University; CARIM School for Cardiovascular Diseases, Universiteit Maastricht; Barts and The London School of Medicine and Dentistry; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; University of Ioannina; UK Dementia Research Institute; H. Lundbeck A/S; Novo Nordisk Foundation Center for Basic Metabolic Research; Medical Research Council; Tartu Ülikool; Uppsala Universitet; Russian Science Foundation; Lomonosov Moscow State University; Ludwig-Maximilians-Universität München; Centre National de la Recherche Scientifique; Université de Lille; King Abdulaziz University; University of Queensland; Karolinska Institutet; Universiteit Maastricht; KU Leuven; Horizon 2020 Framework Programme; Vetenskapsrådet; Deutsches Zentrum für Herz-Kreislaufforschung; Università degli Studi di Trento; Novo Nordisk; Agence Nationale de la Recherche; Hjärt-Lungfonden; Lundbeckfonden; University of South Australia; European Foundation for the Study of Diabetes; University of Glasgow; World Cancer Research Fund International; Erasmus Medisch Centrum; School of Public Health, Imperial College London; University of Oxford; Biotechnology and Biological Sciences Research Council; Nanyang Technological University; Universität Ulm; Society for Endocrinology; British Heart Foundation; Barts Charity; Massachusetts General Hospital; UK Research and Innovation; Lunds Universitet; Vanderbilt Institute for Clinical and Translational Research; European Genomic Institute for Diabetes; Universitetet i Tromsø; Imperial College London; Novo Nordisk Fonden; Università degli Studi di Ferrara; South Australian Health and Medical Research Institute; Norges Teknisk-Naturvitenskapelige Universitet; Alzheimer's Society; Diabetes UK; Research England; Engineering and Physical Sciences Research Council; European Commission; Helsingin Yliopisto; Technische Universität München; University of Exeter; University of Surrey; Amgen; Royal Society; University of North Carolina at Chapel Hill; Science for Life Laboratory; Queen Mary University of London; Vlaamse regering; National Institute for Health and Care Research; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai; Coventry University; Wellcome Trust; Vanderbilt University","keywords":"Biology; Genome-wide association study; Pathophysiology; Diabetes mellitus; Risk stratification; Computational biology; Stratification (seeds); Bioinformatics; Internal medicine; Endocrinology; Genetics; Medicine; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001575315,0.00115538,0.002314695,0.002502575,0.0001600776,0.0008064082,0.0007368691,0.0009301552,0.003669366],"category_scores_gemma":[0.00196765,0.0002944424,0.001053901,0.00252826,0.0003490028,0.0006934584,0.0005602094,0.001150443,0.001956621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006582412,"about_ca_system_score_gemma":0.00117115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001339564,"about_ca_topic_score_gemma":0.002497967,"domain_scores_codex":[0.9996104,0.00011085,0.00006893414,0.00007711258,0.0001039776,0.00002874685],"domain_scores_gemma":[0.9989724,0.0006580302,0.0001104716,0.00003989501,0.0001596673,0.00005945371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002435456,0.00003004774,0.001001402,0.01484688,0.000936662,0.0001736732,0.00003150015,0.000290249,0.001007582,0.002383365,0.01926536,0.9597898],"study_design_scores_gemma":[0.0001029507,0.0001938073,0.008489493,0.008748097,0.002180072,0.001687975,0.00006081841,0.0002142407,0.000850011,0.003716227,0.973707,0.00004945143],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002856723,0.9974555,0.0004149201,0.0004708842,0.0002057005,0.000008961683,0.0001645952,0.00001668488,0.0009771335],"genre_scores_gemma":[0.00221343,0.9954972,0.0006791792,0.0004674218,0.0002104202,0.00001499783,0.0003034347,0.000006005957,0.0006079426],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003669366,"threshold_uncertainty_score":0.01227522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04786816812498351,"score_gpt":0.3710914116177779,"score_spread":0.3232232434927944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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