{"id":"W4386516282","doi":"10.1038/s41588-023-01462-3","title":"GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification","year":2023,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Diabetes Management and Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Helmholtz Zentrum München; Lee Kong Chian School of Medicine, Nanyang Technological University; CARIM School for Cardiovascular Diseases, Universiteit Maastricht; Barts and The London School of Medicine and Dentistry; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; University of Ioannina; UK Dementia Research Institute; H. Lundbeck A/S; Novo Nordisk Foundation Center for Basic Metabolic Research; Medical Research Council; Tartu Ülikool; Uppsala Universitet; Russian Science Foundation; Lomonosov Moscow State University; Ludwig-Maximilians-Universität München; Centre National de la Recherche Scientifique; Université de Lille; King Abdulaziz University; University of Queensland; Karolinska Institutet; Universiteit Maastricht; KU Leuven; Horizon 2020 Framework Programme; Vetenskapsrådet; Deutsches Zentrum für Herz-Kreislaufforschung; Università degli Studi di Trento; Novo Nordisk; Agence Nationale de la Recherche; Hjärt-Lungfonden; Lundbeckfonden; University of South Australia; European Foundation for the Study of Diabetes; University of Glasgow; World Cancer Research Fund International; Erasmus Medisch Centrum; School of Public Health, Imperial College London; University of Oxford; Biotechnology and Biological Sciences Research Council; Nanyang Technological University; Universität Ulm; Society for Endocrinology; British Heart Foundation; Barts Charity; Massachusetts General Hospital; UK Research and Innovation; Lunds Universitet; Vanderbilt Institute for Clinical and Translational Research; European Genomic Institute for Diabetes; Universitetet i Tromsø; Imperial College London; Novo Nordisk Fonden; Università degli Studi di Ferrara; South Australian Health and Medical Research Institute; Norges Teknisk-Naturvitenskapelige Universitet; Alzheimer's Society; Diabetes UK; Research England; Engineering and Physical Sciences Research Council; European Commission; Helsingin Yliopisto; Technische Universität München; University of Exeter; University of Surrey; Amgen; Royal Society; University of North Carolina at Chapel Hill; Science for Life Laboratory; Queen Mary University of London; Vlaamse regering; National Institute for Health and Care Research; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai; Coventry University; Wellcome Trust; Vanderbilt University","keywords":"Biology; Genome-wide association study; Pathophysiology; Diabetes mellitus; Risk stratification; Computational biology; Stratification (seeds); Bioinformatics; Internal medicine; Endocrinology; Genetics; Medicine; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002386994,0.0003125125,0.001257342,0.0005859944,0.00005272213,0.00002583617,0.000197297,0.0006335713,0.000003868653],"category_scores_gemma":[0.0001428665,0.0002145881,0.0001736556,0.0006563362,0.000163614,0.0000241349,0.000128571,0.0005394692,0.00001876564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000102435,"about_ca_system_score_gemma":0.0002289117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000497718,"about_ca_topic_score_gemma":0.00003499777,"domain_scores_codex":[0.9981828,0.0001944633,0.0006200026,0.0004677023,0.0002805062,0.0002544881],"domain_scores_gemma":[0.9985898,0.0003669792,0.0002789542,0.0005542365,0.0001144442,0.00009558259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008599914,0.0002746055,0.0008882272,0.01103078,0.0003814512,0.000003929923,0.0001671775,0.000002222608,0.0001073687,0.0001225191,0.0002329206,0.9867802],"study_design_scores_gemma":[0.0030387,0.0008937713,0.01870596,0.009320941,0.001910436,5.682797e-7,0.00005744516,0.0001824739,0.000244532,0.003687611,0.9615177,0.000439898],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01497583,0.9811125,0.000002081006,0.0001618404,0.00008956955,0.003326318,0.00004437509,0.00003189033,0.000255531],"genre_scores_gemma":[0.003668513,0.9934431,0.0005576623,0.00004540792,0.0001020949,0.0005243164,0.001339858,0.00004608934,0.000272971],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9863403,"threshold_uncertainty_score":0.8750648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04786816812498351,"score_gpt":0.3710914116177779,"score_spread":0.3232232434927944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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