{"id":"W4386523189","doi":"10.1126/science.abq5202","title":"Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Liver physiology and pathology","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University Health Network; University of Calgary","funders":"","keywords":"Cirrhosis; Fibrosis; Biology; Macrophage; Kupffer cell; Immune system; Cell biology; Syncytium; Liver cytology; Pathology; Immunology; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009103072,0.0000625427,0.00009238719,0.0001345793,0.0001671205,0.00001311463,0.0002104919,0.00004968133,0.0001648077],"category_scores_gemma":[0.00009548001,0.00004018773,0.00002878017,0.0009538849,0.0004324794,0.0001027498,0.00007928639,0.0001872734,0.0009638224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002815486,"about_ca_system_score_gemma":0.0001085398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004852489,"about_ca_topic_score_gemma":0.00001360123,"domain_scores_codex":[0.9990181,0.00008919461,0.0001061971,0.0002925631,0.0002263762,0.0002675301],"domain_scores_gemma":[0.9994337,0.0001052999,0.00002785474,0.0003543359,0.00003680948,0.00004197925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005759121,0.0002242042,0.1216755,0.0002549821,0.00001342585,0.002890568,0.0147211,0.0001548851,0.8039007,0.001520315,0.05063311,0.00343535],"study_design_scores_gemma":[0.0002774801,0.0002651887,0.9934776,0.00002127493,0.00001522282,0.00006323658,0.0003810728,0.0002924187,0.003055252,0.0008288671,0.0012687,0.00005365339],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995335,0.0001509247,0.00001587395,0.0006056614,0.0004698438,0.0002010878,0.000001085053,0.00004586985,0.00317466],"genre_scores_gemma":[0.9952734,0.00004216569,0.00003998462,0.001340006,0.00007136403,0.00001415329,0.000004062783,0.000003830155,0.003210998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8718022,"threshold_uncertainty_score":0.999814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137964445475037,"score_gpt":0.2739339430207853,"score_spread":0.2525542985660349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}