{"id":"W4386524843","doi":"10.1371/journal.pbio.3002268","title":"Reservoir host immunology and life history shape virulence evolution in zoonotic viruses","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Zoonotic diseases and public health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Defense Sciences Office, DARPA; University of Chicago; Public Health Agency of Canada; Division of Environmental Biology; Public Health Agency; Advanced Research Projects Agency; Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley; National Institutes of Health; National Science Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Biology; Virulence; Host (biology); Viral evolution; Evolutionary biology; Natural reservoir; Pandemic; Phylogenetics; Virology; Virus; Zoology; Ecology; Genetics; Genome; Gene; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014198,0.000294972,0.0003205198,0.000369812,0.000356217,0.0009936293,0.0005178203,0.000636136,0.001475048],"category_scores_gemma":[0.003599522,0.0002387176,0.0005314387,0.0002091609,0.0005880593,0.0007942474,0.0006877007,0.0006148797,0.0001532806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005111654,"about_ca_system_score_gemma":0.0004236004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002730175,"about_ca_topic_score_gemma":0.0038006,"domain_scores_codex":[0.9996521,0.0001662304,0.00001084176,0.00008421238,0.00001903253,0.00006744935],"domain_scores_gemma":[0.998814,0.0005980864,0.0003293825,0.00008465989,0.00004802527,0.0001259677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003496238,0.000210053,0.7866825,0.000170197,0.0005539081,0.0006355674,0.001313773,0.1276589,0.03723367,0.02229944,0.0007642058,0.02212816],"study_design_scores_gemma":[0.00002953658,0.0003825528,0.4807184,0.00005253496,0.0002535215,0.0006277549,0.001079829,0.4817249,0.002612878,0.03066028,0.001786321,0.00007133418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925011,0.0002693485,0.006136214,0.0001722138,0.000007170808,0.000006632729,0.00006899226,0.00002107867,0.0008173052],"genre_scores_gemma":[0.9987588,0.000106012,0.0009183721,0.00002752872,0.00000340203,0.000003883836,0.00004021143,0.000006605595,0.0001351869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002730175,"threshold_uncertainty_score":0.007508695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06514312954197797,"score_gpt":0.3024674326814617,"score_spread":0.2373243031394837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}