{"id":"W4386524843","doi":"10.1371/journal.pbio.3002268","title":"Reservoir host immunology and life history shape virulence evolution in zoonotic viruses","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Zoonotic diseases and public health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Defense Sciences Office, DARPA; University of Chicago; Public Health Agency of Canada; Division of Environmental Biology; Public Health Agency; Advanced Research Projects Agency; Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley; National Institutes of Health; National Science Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Biology; Virulence; Host (biology); Viral evolution; Evolutionary biology; Natural reservoir; Pandemic; Phylogenetics; Virology; Virus; Zoology; Ecology; Genetics; Genome; Gene; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029238,0.0001169531,0.0003207434,0.000321836,0.00003994199,0.000003357988,0.00009790913,0.0001854324,0.0005699898],"category_scores_gemma":[0.001187783,0.000103098,0.00003416286,0.0002536221,0.000240583,0.00005763997,0.00009958669,0.0002221121,0.0002718997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683145,"about_ca_system_score_gemma":0.0005521388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006635123,"about_ca_topic_score_gemma":0.00009098137,"domain_scores_codex":[0.9987382,0.0001616179,0.000283149,0.0003322098,0.0000714835,0.0004133282],"domain_scores_gemma":[0.9992038,0.0002256985,0.00006273719,0.0002550617,0.0000495415,0.0002031685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001330588,0.0008863839,0.8986201,0.0008311679,0.0002569542,0.0001997229,0.001351084,0.000006239321,0.04791271,0.03180214,0.008110994,0.008691939],"study_design_scores_gemma":[0.001308454,0.000670523,0.9647855,0.0001027606,0.0000403083,0.0000148405,0.0004237418,0.003052302,0.00003002332,0.001111852,0.02829759,0.0001620877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889792,0.004730224,0.000008991854,0.003857468,0.0003133056,0.000260131,0.00001535742,0.0001316153,0.001703743],"genre_scores_gemma":[0.9961438,0.0007852699,0.00005393057,0.002580507,0.0001370085,0.00004239843,0.00003946666,0.00001489455,0.0002027452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06616544,"threshold_uncertainty_score":0.6240989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06514312954197797,"score_gpt":0.3024674326814617,"score_spread":0.2373243031394837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}