{"id":"W4386527000","doi":"10.1186/s13073-023-01219-x","title":"Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours","year":2023,"lang":"en","type":"article","venue":"Genome Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; SickKids Foundation; University Health Network; University of Toronto; BC Cancer Agency; Princess Margaret Cancer Centre; Hospital for Sick Children; University of British Columbia","funders":"NHLBI Division of Intramural Research; Stanford Cancer Institute; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Deutsche Krebshilfe; Terry Fox Research Institute; University of Toronto; Parker Institute for Cancer Immunotherapy","keywords":"Human genetics; Medicine; Central nervous system; Nervous system; Systems biology; Computational biology; Immunology; Biology; Bioinformatics; Neuroscience; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001864029,0.0003324519,0.001213308,0.002284782,0.0001230889,0.00001713184,0.0003742925,0.0001896066,0.003262633],"category_scores_gemma":[0.0001763169,0.0002552808,0.0003806904,0.005650631,0.0003128801,0.000059553,0.0001048043,0.0006294805,0.000417597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008756206,"about_ca_system_score_gemma":0.0001325142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003409515,"about_ca_topic_score_gemma":0.00004855779,"domain_scores_codex":[0.9963118,0.0003183172,0.0009326281,0.0006503894,0.000918204,0.0008685988],"domain_scores_gemma":[0.9984533,0.0003080423,0.0001339734,0.0006833014,0.000129036,0.0002923322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002847342,0.0002904899,0.1847109,0.0007872029,0.002343077,0.00324784,0.003004506,0.001221873,0.784351,0.0003238928,0.0007208953,0.01615095],"study_design_scores_gemma":[0.004229248,0.0006750245,0.9867169,0.0001101562,0.0009109793,0.0001935702,0.002171696,0.001536527,0.00003092453,0.00004231948,0.003125455,0.0002572548],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840443,0.007716849,0.0002108311,0.003485826,0.0003285026,0.0009177754,0.00004262317,0.0002874004,0.002965878],"genre_scores_gemma":[0.991218,0.001144076,0.00005488704,0.0001783439,0.0007103657,0.000117234,0.0007215237,0.00005169224,0.005803888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8020059,"threshold_uncertainty_score":0.9999899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03392925098274058,"score_gpt":0.2945778025462837,"score_spread":0.2606485515635431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}